Depression drug treatment outcomes in pregnancy and the postpartum period

A systematic review and meta-analysis

Marian McDonagh, Annette Matthews, Carrie Phillipi, Jill (Jillian) Romm, Kim Peterson, Sujata Thakurta, Jeanne-Marie Guise

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the comparative benefits and harms in both mother and child of antidepressant treatment for depression in pregnant or postpartum women. DATA SOURCES: MEDLINE, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov (inception to July 2013), manufacturers, and reference lists. METHODS OF STUDY SELECTION: Two reviewers independently selected studies of pregnant women with depression comparing antidepressants with each other, placebo or no treatment, or nondrug treatments. Studies making comparisons among women taking antidepressants for any reason and those not taking antidepressants (depression status unknown) were used to fill gaps in the evidence. TABULATION, INTEGRATION, AND RESULTS: Dual study data extraction and quality assessment were used. Six randomized controlled trials and 15 observational studies provided evidence. Low-strength evidence suggested neonates of pregnant women with depression taking selective serotonin reuptake inhibitors had higher risk of respiratory distress than did neonates of untreated women (13.9% compared with 7.8%; P

Original languageEnglish (US)
Pages (from-to)526-534
Number of pages9
JournalObstetrics and Gynecology
Volume124
Issue number3
DOIs
StatePublished - 2014

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Postpartum Period
Antidepressive Agents
Meta-Analysis
Depression
Pregnant Women
Pregnancy
Pharmaceutical Preparations
Newborn Infant
Serotonin Uptake Inhibitors
MEDLINE
Libraries
Observational Studies
Therapeutics
Randomized Controlled Trials
Placebos
Mothers

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Depression drug treatment outcomes in pregnancy and the postpartum period : A systematic review and meta-analysis. / McDonagh, Marian; Matthews, Annette; Phillipi, Carrie; Romm, Jill (Jillian); Peterson, Kim; Thakurta, Sujata; Guise, Jeanne-Marie.

In: Obstetrics and Gynecology, Vol. 124, No. 3, 2014, p. 526-534.

Research output: Contribution to journalArticle

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