Depression and its association with peritonitis in long-term peritoneal dialysis patients

Laura Troidle, Suzanne Watnick, Diane B. Wuerth, Nancy Gorban-Brennan, Alan S. Kliger, Fredric O. Finkelstein

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Background: Depression is the most common psychological disorder among patients with end-stage renal disease and has been associated with mortality in patients maintained on hemodialysis therapy. Peritonitis is the leading cause of technique failure among long-term peritoneal dialysis (PD) patients. This prospective study is designed to examine the relationship between depression and peritonitis. Methods: All patients on long-term PD therapy in our unit between January 1, 1997, and January 31, 2002, completed a Beck Depression Inventory (BDI) assessment at 6-month intervals. BDI scores were analyzed 2 ways. First, patients were placed into either group I (BDI score <10) or group II (BDI score ≥ 11) and were reclassified based on subsequent scores. Second, multivariable analysis was performed looking at initial BDI score as a risk factor for peritonitis, adjusting for age older than 65 years, diabetes, coronary artery disease, and race. Results: One hundred sixty-two patients were enrolled, and 281 individual BDI assessments were completed. There was a significantly greater incidence of diabetes and coronary artery disease in group II. Rates for overall and gram-positive peritonitis were significantly greater in group II patients compared with group I patients. Using Cox regression, only BDI score of 11 or greater was associated with the development of peritonitis (hazard ratio, 2.7; 95% confidence interval, 1.2 to 6.0). Conclusion: There is an association between BDI score of 11 or greater and the development of peritonitis. Whether treatment of depression can impact on the rate of peritonitis remains to be examined.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume42
Issue number2
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

Peritoneal Dialysis
Peritonitis
Equipment and Supplies
Coronary Artery Disease
Chronic Kidney Failure
Renal Dialysis
Therapeutics
Prospective Studies
Confidence Intervals
Psychology
Mortality
Incidence

Keywords

  • Depression
  • End-stage renal disease (ESRD)
  • Long-term peritoneal dialysis (PD)
  • Peritonitis

ASJC Scopus subject areas

  • Nephrology

Cite this

Troidle, L., Watnick, S., Wuerth, D. B., Gorban-Brennan, N., Kliger, A. S., & Finkelstein, F. O. (2003). Depression and its association with peritonitis in long-term peritoneal dialysis patients. American Journal of Kidney Diseases, 42(2), 350-354. https://doi.org/10.1016/S0272-6386(03)00661-9

Depression and its association with peritonitis in long-term peritoneal dialysis patients. / Troidle, Laura; Watnick, Suzanne; Wuerth, Diane B.; Gorban-Brennan, Nancy; Kliger, Alan S.; Finkelstein, Fredric O.

In: American Journal of Kidney Diseases, Vol. 42, No. 2, 01.08.2003, p. 350-354.

Research output: Contribution to journalArticle

Troidle, L, Watnick, S, Wuerth, DB, Gorban-Brennan, N, Kliger, AS & Finkelstein, FO 2003, 'Depression and its association with peritonitis in long-term peritoneal dialysis patients', American Journal of Kidney Diseases, vol. 42, no. 2, pp. 350-354. https://doi.org/10.1016/S0272-6386(03)00661-9
Troidle, Laura ; Watnick, Suzanne ; Wuerth, Diane B. ; Gorban-Brennan, Nancy ; Kliger, Alan S. ; Finkelstein, Fredric O. / Depression and its association with peritonitis in long-term peritoneal dialysis patients. In: American Journal of Kidney Diseases. 2003 ; Vol. 42, No. 2. pp. 350-354.
@article{52658629e01847978bff09a49b13d3d2,
title = "Depression and its association with peritonitis in long-term peritoneal dialysis patients",
abstract = "Background: Depression is the most common psychological disorder among patients with end-stage renal disease and has been associated with mortality in patients maintained on hemodialysis therapy. Peritonitis is the leading cause of technique failure among long-term peritoneal dialysis (PD) patients. This prospective study is designed to examine the relationship between depression and peritonitis. Methods: All patients on long-term PD therapy in our unit between January 1, 1997, and January 31, 2002, completed a Beck Depression Inventory (BDI) assessment at 6-month intervals. BDI scores were analyzed 2 ways. First, patients were placed into either group I (BDI score <10) or group II (BDI score ≥ 11) and were reclassified based on subsequent scores. Second, multivariable analysis was performed looking at initial BDI score as a risk factor for peritonitis, adjusting for age older than 65 years, diabetes, coronary artery disease, and race. Results: One hundred sixty-two patients were enrolled, and 281 individual BDI assessments were completed. There was a significantly greater incidence of diabetes and coronary artery disease in group II. Rates for overall and gram-positive peritonitis were significantly greater in group II patients compared with group I patients. Using Cox regression, only BDI score of 11 or greater was associated with the development of peritonitis (hazard ratio, 2.7; 95{\%} confidence interval, 1.2 to 6.0). Conclusion: There is an association between BDI score of 11 or greater and the development of peritonitis. Whether treatment of depression can impact on the rate of peritonitis remains to be examined.",
keywords = "Depression, End-stage renal disease (ESRD), Long-term peritoneal dialysis (PD), Peritonitis",
author = "Laura Troidle and Suzanne Watnick and Wuerth, {Diane B.} and Nancy Gorban-Brennan and Kliger, {Alan S.} and Finkelstein, {Fredric O.}",
year = "2003",
month = "8",
day = "1",
doi = "10.1016/S0272-6386(03)00661-9",
language = "English (US)",
volume = "42",
pages = "350--354",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Depression and its association with peritonitis in long-term peritoneal dialysis patients

AU - Troidle, Laura

AU - Watnick, Suzanne

AU - Wuerth, Diane B.

AU - Gorban-Brennan, Nancy

AU - Kliger, Alan S.

AU - Finkelstein, Fredric O.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Background: Depression is the most common psychological disorder among patients with end-stage renal disease and has been associated with mortality in patients maintained on hemodialysis therapy. Peritonitis is the leading cause of technique failure among long-term peritoneal dialysis (PD) patients. This prospective study is designed to examine the relationship between depression and peritonitis. Methods: All patients on long-term PD therapy in our unit between January 1, 1997, and January 31, 2002, completed a Beck Depression Inventory (BDI) assessment at 6-month intervals. BDI scores were analyzed 2 ways. First, patients were placed into either group I (BDI score <10) or group II (BDI score ≥ 11) and were reclassified based on subsequent scores. Second, multivariable analysis was performed looking at initial BDI score as a risk factor for peritonitis, adjusting for age older than 65 years, diabetes, coronary artery disease, and race. Results: One hundred sixty-two patients were enrolled, and 281 individual BDI assessments were completed. There was a significantly greater incidence of diabetes and coronary artery disease in group II. Rates for overall and gram-positive peritonitis were significantly greater in group II patients compared with group I patients. Using Cox regression, only BDI score of 11 or greater was associated with the development of peritonitis (hazard ratio, 2.7; 95% confidence interval, 1.2 to 6.0). Conclusion: There is an association between BDI score of 11 or greater and the development of peritonitis. Whether treatment of depression can impact on the rate of peritonitis remains to be examined.

AB - Background: Depression is the most common psychological disorder among patients with end-stage renal disease and has been associated with mortality in patients maintained on hemodialysis therapy. Peritonitis is the leading cause of technique failure among long-term peritoneal dialysis (PD) patients. This prospective study is designed to examine the relationship between depression and peritonitis. Methods: All patients on long-term PD therapy in our unit between January 1, 1997, and January 31, 2002, completed a Beck Depression Inventory (BDI) assessment at 6-month intervals. BDI scores were analyzed 2 ways. First, patients were placed into either group I (BDI score <10) or group II (BDI score ≥ 11) and were reclassified based on subsequent scores. Second, multivariable analysis was performed looking at initial BDI score as a risk factor for peritonitis, adjusting for age older than 65 years, diabetes, coronary artery disease, and race. Results: One hundred sixty-two patients were enrolled, and 281 individual BDI assessments were completed. There was a significantly greater incidence of diabetes and coronary artery disease in group II. Rates for overall and gram-positive peritonitis were significantly greater in group II patients compared with group I patients. Using Cox regression, only BDI score of 11 or greater was associated with the development of peritonitis (hazard ratio, 2.7; 95% confidence interval, 1.2 to 6.0). Conclusion: There is an association between BDI score of 11 or greater and the development of peritonitis. Whether treatment of depression can impact on the rate of peritonitis remains to be examined.

KW - Depression

KW - End-stage renal disease (ESRD)

KW - Long-term peritoneal dialysis (PD)

KW - Peritonitis

UR - http://www.scopus.com/inward/record.url?scp=0043128783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043128783&partnerID=8YFLogxK

U2 - 10.1016/S0272-6386(03)00661-9

DO - 10.1016/S0272-6386(03)00661-9

M3 - Article

C2 - 12900818

AN - SCOPUS:0043128783

VL - 42

SP - 350

EP - 354

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 2

ER -