Depression after Stroke: A Prospective Epidemiological Study

Ellen M. Whyte, Benoit H. Mulsant, Joni Vanderbilt, Hiroko Dodge, Mary Ganguli

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

OBJECTIVES: To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship. DESIGN: A prospective longitudinal epidemiological survey. SETTING: The mid-Monongahela Valley, a rural, non-farm, low-socioeconomic-status community. PARTICIPANTS: Random sample of 1,134 subjects aged 65 and older. MEASUREMENTS: The dependent variable was clinically significant depressive symptoms, as defined by five or more symptoms on the modified Center for Epidemiological Studies Depression scale. The independent variables were demographics (age, sex, education), stroke, number of impaired instrumental activities of daily living (IADLs), diabetes mellitus, hypertension, atherosclerotic heart disease, and smoking. Logistic regression analyses were conducted for cross-sectional and longitudinal models examining whether stroke was associated with or predicted depressive symptoms, with other associated factors included as covariates. RESULTS: Clinically significant depressive symptoms were cross-sectionally associated with stroke (odds ratio (OR) = 3.5, 95% confidence interval (CI) = 1.4-8.3), diabetes mellitus (OR = 2.8, 95% CI = 1.7-4.6; P ≤ .05), and IADL impairment (OR = 1.6, 95% CI = 1.4-1.8; P

Original languageEnglish (US)
Pages (from-to)774-778
Number of pages5
JournalJournal of the American Geriatrics Society
Volume52
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Epidemiologic Studies
Stroke
Prospective Studies
Depression
Odds Ratio
Confidence Intervals
Activities of Daily Living
Diabetes Mellitus
Sex Education
Social Class
Longitudinal Studies
Heart Diseases
Logistic Models
Smoking
Regression Analysis
Demography
Hypertension

Keywords

  • Cerebrovascular risk factors
  • Depression
  • Disability
  • Older adults
  • Stroke

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Depression after Stroke : A Prospective Epidemiological Study. / Whyte, Ellen M.; Mulsant, Benoit H.; Vanderbilt, Joni; Dodge, Hiroko; Ganguli, Mary.

In: Journal of the American Geriatrics Society, Vol. 52, No. 5, 05.2004, p. 774-778.

Research output: Contribution to journalArticle

Whyte, Ellen M. ; Mulsant, Benoit H. ; Vanderbilt, Joni ; Dodge, Hiroko ; Ganguli, Mary. / Depression after Stroke : A Prospective Epidemiological Study. In: Journal of the American Geriatrics Society. 2004 ; Vol. 52, No. 5. pp. 774-778.
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