Depressed lymphocyte responsiveness in autistic children

E. Gene Stubbs; Mary Lou Crawford; Denis R. Burger; Arthur A. Vandenbark

doi:10.1007/BF01531114

Depressed lymphocyte responsiveness in autistic children

E. Gene Stubbs, Mary Lou Crawford, Denis R. Burger, Arthur A. Vandenbark

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Abstract

Although there are associations linking autism with prenatal rubella, cytomegalovirus, syphilis, and varicella, the etiology of the autistic state remains obscure. Host defense against the etiologic agents postulated to be responsible for the autism-associated syndromes is believed to be primarily of the cell-mediated type. In this preliminary study, cellular immune function was assessed in vitro by phytohemagglutinin (PHA)stimulation of lymphocyte cultures. Twelve autistic children and 13 control subjects were compared. The autistic group exhibited a depressed lymphocyte transformation response to PHA when compared to the control subjects (p<.01).

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Journal of Autism and Childhood Schizophrenia
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF01531114
State	Published - Mar 1977
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Psychiatry and Mental health

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10.1007/BF01531114

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AU - Burger, Denis R.

AU - Vandenbark, Arthur A.

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Depressed lymphocyte responsiveness in autistic children

Abstract

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