Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients

Susan K. Lutgendorf, Donald M. Lamkin, Koen DeGeest, Barrie Anderson, Minh Dao, Stephanie McGinn, Bridget Zimmerman, Heena Maiseri, Anil K. Sood, David M. Lubaroff

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48 Scopus citations

Abstract

The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4+) and T-cytotoxic (CD8+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values < 0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values < 0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4+ cells producing IFNγ (TH1 cells) vs. IL-4 (TH2 cells) in all compartments (depressed mood: P = 0.012; anxiety: P = 0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8+ cells producing IFNγ (TC1) vs. IL-4 (TC2) (P = 0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.

Original languageEnglish (US)
Pages (from-to)890-900
Number of pages11
JournalBrain, Behavior, and Immunity
Volume22
Issue number6
DOIs
StatePublished - Aug 1 2008

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Keywords

  • Anxiety
  • Cytokines
  • Depressed mood
  • Distress
  • Ovarian cancer
  • Psychoneuroimmunology
  • T-cell response
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Lutgendorf, S. K., Lamkin, D. M., DeGeest, K., Anderson, B., Dao, M., McGinn, S., Zimmerman, B., Maiseri, H., Sood, A. K., & Lubaroff, D. M. (2008). Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. Brain, Behavior, and Immunity, 22(6), 890-900. https://doi.org/10.1016/j.bbi.2007.12.012