Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients

Susan K. Lutgendorf, Donald M. Lamkin, Koenraad De Geest, Barrie Anderson, Minh Dao, Stephanie McGinn, Bridget Zimmerman, Heena Maiseri, Anil K. Sood, David M. Lubaroff

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4+) and T-cytotoxic (CD8+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values <0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values <0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4+ cells producing IFNγ (TH1 cells) vs. IL-4 (TH2 cells) in all compartments (depressed mood: P = 0.012; anxiety: P = 0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8+ cells producing IFNγ (TC1) vs. IL-4 (TC2) (P = 0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.

Original languageEnglish (US)
Pages (from-to)890-900
Number of pages11
JournalBrain, Behavior, and Immunity
Volume22
Issue number6
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Cytokines
T-Lymphocytes
Adaptive Immunity
Interleukin-4
Population
Interferon-gamma
Neoplasms
Tumor Microenvironment
Ascites
Anxiety
Lymphocytes
Tumor-Infiltrating Lymphocytes
Interferon Type I
Ambulatory Surgical Procedures
Survival

Keywords

  • Anxiety
  • Cytokines
  • Depressed mood
  • Distress
  • Ovarian cancer
  • Psychoneuroimmunology
  • T-cell response
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. / Lutgendorf, Susan K.; Lamkin, Donald M.; De Geest, Koenraad; Anderson, Barrie; Dao, Minh; McGinn, Stephanie; Zimmerman, Bridget; Maiseri, Heena; Sood, Anil K.; Lubaroff, David M.

In: Brain, Behavior, and Immunity, Vol. 22, No. 6, 08.2008, p. 890-900.

Research output: Contribution to journalArticle

Lutgendorf, SK, Lamkin, DM, De Geest, K, Anderson, B, Dao, M, McGinn, S, Zimmerman, B, Maiseri, H, Sood, AK & Lubaroff, DM 2008, 'Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients', Brain, Behavior, and Immunity, vol. 22, no. 6, pp. 890-900. https://doi.org/10.1016/j.bbi.2007.12.012
Lutgendorf, Susan K. ; Lamkin, Donald M. ; De Geest, Koenraad ; Anderson, Barrie ; Dao, Minh ; McGinn, Stephanie ; Zimmerman, Bridget ; Maiseri, Heena ; Sood, Anil K. ; Lubaroff, David M. / Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. In: Brain, Behavior, and Immunity. 2008 ; Vol. 22, No. 6. pp. 890-900.
@article{a0ee01ba38ce4f538930b2e2cf880459,
title = "Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients",
abstract = "The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4+) and T-cytotoxic (CD8+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values <0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values <0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4+ cells producing IFNγ (TH1 cells) vs. IL-4 (TH2 cells) in all compartments (depressed mood: P = 0.012; anxiety: P = 0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8+ cells producing IFNγ (TC1) vs. IL-4 (TC2) (P = 0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.",
keywords = "Anxiety, Cytokines, Depressed mood, Distress, Ovarian cancer, Psychoneuroimmunology, T-cell response, Tumor microenvironment",
author = "Lutgendorf, {Susan K.} and Lamkin, {Donald M.} and {De Geest}, Koenraad and Barrie Anderson and Minh Dao and Stephanie McGinn and Bridget Zimmerman and Heena Maiseri and Sood, {Anil K.} and Lubaroff, {David M.}",
year = "2008",
month = "8",
doi = "10.1016/j.bbi.2007.12.012",
language = "English (US)",
volume = "22",
pages = "890--900",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients

AU - Lutgendorf, Susan K.

AU - Lamkin, Donald M.

AU - De Geest, Koenraad

AU - Anderson, Barrie

AU - Dao, Minh

AU - McGinn, Stephanie

AU - Zimmerman, Bridget

AU - Maiseri, Heena

AU - Sood, Anil K.

AU - Lubaroff, David M.

PY - 2008/8

Y1 - 2008/8

N2 - The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4+) and T-cytotoxic (CD8+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values <0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values <0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4+ cells producing IFNγ (TH1 cells) vs. IL-4 (TH2 cells) in all compartments (depressed mood: P = 0.012; anxiety: P = 0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8+ cells producing IFNγ (TC1) vs. IL-4 (TC2) (P = 0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.

AB - The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4+) and T-cytotoxic (CD8+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (P values <0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (P values <0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4+ cells producing IFNγ (TH1 cells) vs. IL-4 (TH2 cells) in all compartments (depressed mood: P = 0.012; anxiety: P = 0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8+ cells producing IFNγ (TC1) vs. IL-4 (TC2) (P = 0.035). Although effects of polyclonal stimulation should be generalized with caution to the in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.

KW - Anxiety

KW - Cytokines

KW - Depressed mood

KW - Distress

KW - Ovarian cancer

KW - Psychoneuroimmunology

KW - T-cell response

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=46049102610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46049102610&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2007.12.012

DO - 10.1016/j.bbi.2007.12.012

M3 - Article

C2 - 18276105

AN - SCOPUS:46049102610

VL - 22

SP - 890

EP - 900

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

IS - 6

ER -