Depletion of 9L rat brain tumor cell polyamine content by treatment with d,l-α-difluoromethylornithine inhibits proliferation and the G1 to S transition

Jerome Seidenfeld, Joe Gray, Laurence J. Marton

Research output: Contribution to journalArticle

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Abstract

d,l-α-Difluoromethylornithine (DFMO), an irreversible inactivator of ornithine decarboxylase, inhibited 9L monolayer culture rat brain tumor cell proliferation at concentrations as low as 1 mM DFMO to about 25% of control growth when cells were seeded at an initial density of 5 × 105/flask. DFMO reduced intracellular putrescine content to

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalExperimental Cell Research
Volume131
Issue number1
DOIs
StatePublished - 1981
Externally publishedYes

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Eflornithine
Polyamines
Brain Neoplasms
Ornithine Decarboxylase
Putrescine
Cell Proliferation
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Depletion of 9L rat brain tumor cell polyamine content by treatment with d,l-α-difluoromethylornithine inhibits proliferation and the G1 to S transition. / Seidenfeld, Jerome; Gray, Joe; Marton, Laurence J.

In: Experimental Cell Research, Vol. 131, No. 1, 1981, p. 209-216.

Research output: Contribution to journalArticle

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