Abstract
d,l-α-Difluoromethylornithine (DFMO), an irreversible inactivator of ornithine decarboxylase, inhibited 9L monolayer culture rat brain tumor cell proliferation at concentrations as low as 1 mM DFMO to about 25% of control growth when cells were seeded at an initial density of 5 × 105/flask. DFMO reduced intracellular putrescine content to
| Original language | English (US) |
|---|---|
| Pages (from-to) | 209-216 |
| Number of pages | 8 |
| Journal | Experimental Cell Research |
| Volume | 131 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Depletion of 9L rat brain tumor cell polyamine content by treatment with d,l-α-difluoromethylornithine inhibits proliferation and the G1 to S transition. / Seidenfeld, Jerome; Gray, Joe; Marton, Laurence J.
In: Experimental Cell Research, Vol. 131, No. 1, 1981, p. 209-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depletion of 9L rat brain tumor cell polyamine content by treatment with d,l-α-difluoromethylornithine inhibits proliferation and the G1 to S transition
AU - Seidenfeld, Jerome
AU - Gray, Joe
AU - Marton, Laurence J.
PY - 1981
Y1 - 1981
N2 - d,l-α-Difluoromethylornithine (DFMO), an irreversible inactivator of ornithine decarboxylase, inhibited 9L monolayer culture rat brain tumor cell proliferation at concentrations as low as 1 mM DFMO to about 25% of control growth when cells were seeded at an initial density of 5 × 105/flask. DFMO reduced intracellular putrescine content to
AB - d,l-α-Difluoromethylornithine (DFMO), an irreversible inactivator of ornithine decarboxylase, inhibited 9L monolayer culture rat brain tumor cell proliferation at concentrations as low as 1 mM DFMO to about 25% of control growth when cells were seeded at an initial density of 5 × 105/flask. DFMO reduced intracellular putrescine content to
UR - http://www.scopus.com/inward/record.url?scp=0019366276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019366276&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(81)90420-1
DO - 10.1016/0014-4827(81)90420-1
M3 - Article
VL - 131
SP - 209
EP - 216
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -