Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus

P. J. Conn, A. Janowsky, E. Sanders-Bush

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.

Original languageEnglish (US)
Pages (from-to)396-398
Number of pages3
JournalBrain research
Volume400
Issue number2
DOIs
StatePublished - Jan 6 1987

Keywords

  • 5-HT-1c receptor
  • Cerebrospinal fluid
  • Choroid plexus
  • Phosphoinositide hydrolysis
  • Serotonergic denervation
  • Serotonin receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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