Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus

P. J. Conn, Aaron Janowsky, E. Sanders-Bush

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.

Original languageEnglish (US)
Pages (from-to)396-398
Number of pages3
JournalBrain Research
Volume400
Issue number2
DOIs
StatePublished - Jan 6 1987
Externally publishedYes

Fingerprint

Choroid Plexus
Serotonin Receptors
Denervation
Serotonin
Phosphatidylinositols
Dihydroxytryptamines
Hydrolysis

Keywords

  • 5-HT-1c receptor
  • Cerebrospinal fluid
  • Choroid plexus
  • Phosphoinositide hydrolysis
  • Serotonergic denervation
  • Serotonin receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. / Conn, P. J.; Janowsky, Aaron; Sanders-Bush, E.

In: Brain Research, Vol. 400, No. 2, 06.01.1987, p. 396-398.

Research output: Contribution to journalArticle

Conn, P. J. ; Janowsky, Aaron ; Sanders-Bush, E. / Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. In: Brain Research. 1987 ; Vol. 400, No. 2. pp. 396-398.
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