Dendritic computation of direction selectivity by retinal ganglion cells

W. R. Taylor, S. He, W. R. Levick, D. I. Vaney

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

Direction-selective ganglion cells (DSGCs) in the retina respond strongly when stimulated by image motion in a preferred direction but are only weakly excited by image motion in the opposite null direction. Such coding represents an early manifestation of complex information processing in the visual system, but the cellular locus and the synaptic mechanisms have yet to be elucidated. We recorded the synaptic activity of DSGCs using strategies to observe the asymmetric inhibitory inputs that underlie the generation of direction selectivity. The critical nonlinear interactions between the excitatory and inhibitory inputs took place postsynaptically within the dendrites of the DSGCs.

Original languageEnglish (US)
Pages (from-to)2347-2350
Number of pages4
JournalScience
Volume289
Issue number5488
DOIs
StatePublished - Sep 29 2000

ASJC Scopus subject areas

  • General

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