Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

Johanna Olweus, Andrew BitMansour, Roger Warnke, Peter A. Thompson, Jose Carballido, Louis Picker, Fridtjof Lund-Johansen

Research output: Contribution to journalArticle

369 Citations (Scopus)

Abstract

Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best- characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli. Here, we demonstrate that a large subset of DC in the T cell-dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor α chain (IL-3Rα(hi)). The CD34+IL-3Rα(hi) DC progenitors are of myeloid origin and are distinct from those that give rise to Langerhans cells in vitro. The IL-3Rα(hi) DC furthermore appear to migrate to lymphoid organs independently of inflammatory stimuli or foreign antigens. Thus, DC are heterogeneous with regard to function and ontogeny.

Original languageEnglish (US)
Pages (from-to)12551-12556
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number23
DOIs
StatePublished - Nov 11 1997
Externally publishedYes

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Cell Lineage
Dendritic Cells
Interleukin-3 Receptors
Langerhans Cells
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Genetics
  • General

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Dendritic cell ontogeny : A human dendritic cell lineage of myeloid origin. / Olweus, Johanna; BitMansour, Andrew; Warnke, Roger; Thompson, Peter A.; Carballido, Jose; Picker, Louis; Lund-Johansen, Fridtjof.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 23, 11.11.1997, p. 12551-12556.

Research output: Contribution to journalArticle

Olweus, Johanna ; BitMansour, Andrew ; Warnke, Roger ; Thompson, Peter A. ; Carballido, Jose ; Picker, Louis ; Lund-Johansen, Fridtjof. / Dendritic cell ontogeny : A human dendritic cell lineage of myeloid origin. In: Proceedings of the National Academy of Sciences of the United States of America. 1997 ; Vol. 94, No. 23. pp. 12551-12556.
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