Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials

Dariya I. Malyarenko, David Newitt, Lisa J. Wilmes, Alina Tudorica, Karl G. Helmer, Lori R. Arlinghaus, Michael A. Jacobs, Guido Jajamovich, Bachir Taouli, Thomas E. Yankeelov, Wei Huang, Thomas L. Chenevert

Research output: Research - peer-reviewArticle

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Abstract

Purpose: Characterize system-specific bias across common magnetic resonance imaging (MRI) platforms for quantitative diffusion measurements in multicenter trials. Methods: Diffusion weighted imaging (DWI) was performed on an ice-water phantom along the superior-inferior (SI) and right-left (RL) orientations spanning ±150 mm. The same scanning protocol was implemented on 14 MRI systems at seven imaging centers. The bias was estimated as a deviation of measured from known apparent diffusion coefficient (ADC) along individual DWI directions. The relative contributions of gradient nonlinearity, shim errors, imaging gradients, and eddy currents were assessed independently. The observed bias errors were compared with numerical models. Results: The measured systematic ADC errors scaled quadratically with offset from isocenter, and ranged between -55% (SI) and 25% (RL). Nonlinearity bias was dependent on system design and diffusion gradient direction. Consistent with numerical models, minor ADC errors (±5%) due to shim, imaging and eddy currents were mitigated by double echo DWI and image coregistration of individual gradient directions. Conclusion: The analysis confirms gradient nonlinearity as a major source of spatial DW bias and variability in off-center ADC measurements across MRI platforms, with minor contributions from shim, imaging gradients and eddy currents. The developed protocol enables empiric description of systematic bias in multicenter quantitative DWI studies.

LanguageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - 2015

Fingerprint

Multicenter Studies
Magnetic Resonance Imaging
Direction compound
Ice
Water

Keywords

  • ADC mapping
  • Gradient nonlinearity
  • Multicenter trials
  • Quantitative diffusion MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Malyarenko, D. I., Newitt, D., J. Wilmes, L., Tudorica, A., Helmer, K. G., Arlinghaus, L. R., ... Chenevert, T. L. (2015). Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials. Magnetic Resonance in Medicine. DOI: 10.1002/mrm.25754

Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials. / Malyarenko, Dariya I.; Newitt, David; J. Wilmes, Lisa; Tudorica, Alina; Helmer, Karl G.; Arlinghaus, Lori R.; Jacobs, Michael A.; Jajamovich, Guido; Taouli, Bachir; Yankeelov, Thomas E.; Huang, Wei; Chenevert, Thomas L.

In: Magnetic Resonance in Medicine, 2015.

Research output: Research - peer-reviewArticle

Malyarenko, DI, Newitt, D, J. Wilmes, L, Tudorica, A, Helmer, KG, Arlinghaus, LR, Jacobs, MA, Jajamovich, G, Taouli, B, Yankeelov, TE, Huang, W & Chenevert, TL 2015, 'Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials' Magnetic Resonance in Medicine. DOI: 10.1002/mrm.25754
Malyarenko, Dariya I. ; Newitt, David ; J. Wilmes, Lisa ; Tudorica, Alina ; Helmer, Karl G. ; Arlinghaus, Lori R. ; Jacobs, Michael A. ; Jajamovich, Guido ; Taouli, Bachir ; Yankeelov, Thomas E. ; Huang, Wei ; Chenevert, Thomas L./ Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials. In: Magnetic Resonance in Medicine. 2015
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