Demonstration of Interleukin 6 in Middle Ear Effusions

Robert F. Yellon, Gerald Leonard, James Sidman, Robert Carpenter, Joseph Burleson, Phillip Marucha, Donald Kreutzer, James Carlson

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

In response to infection in the middle ear, inflammatory cells produce cytokines-potent regulators and mediators of the immune response. In an earlier study, we demonstrated that levels of the cytokine interleukin 1 were higher in middle-ear effusions from younger children, while levels of the cytokine tumor necrosis factor were higher in middle-ear effusions from older children and in those requiring tympanostomy on multiple occasions. In this study, we evaluated middle-ear effusions for levels of the cytokine interleukin 6. Activities of interleukin 6 include stimulation of bone erosion and production of antibodies and fever. Using an enzyme-linked immunosorbent assay system, significant levels of interleukin 6 (>0.2 pg/mL) were found in 14 (36%) of 39 middle-ear effusions from 25 children with otitis media with effusion. The mean (±SE) level of interleukin 6 in middle-ear effusions was 173.9± 74.7 pg/mg of total protein. Like interleukin 1, levels of interleukin 6 were higher in younger children. Tumor necrosis factor may be an important regulator of the local immune response in the middle-ear cleft during persistence of otitis media with effusion, while interleukin 1 and interleukin 6 may be important regulators during the early stages of otitis media with effusion. (Arch Otolaryngol Head Neck Surg. 1992;118:745-748).

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume118
Issue number7
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Demonstration of Interleukin 6 in Middle Ear Effusions'. Together they form a unique fingerprint.

  • Cite this

    Yellon, R. F., Leonard, G., Sidman, J., Carpenter, R., Burleson, J., Marucha, P., Kreutzer, D., & Carlson, J. (1992). Demonstration of Interleukin 6 in Middle Ear Effusions. Archives of Otolaryngology--Head and Neck Surgery, 118(7), 745-748. https://doi.org/10.1001/archotol.1992.01880070075014