Demonstration of δRec-pseudo Jα rearrangement with deletion of the δ locus in a human stem-cell leukemia

C. G. Begley, P. D. Aplan, M. P. Davey, J. P. De Villartay, D. I. Cohen, T. A. Waldmann, I. R. Kirsch

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

It has been hypothesized that a rearrangement between the δ recombining element (δRec) and a pseudo Jα gene serves to delete the TCR-δ locus before rearrangement of the TCR-α genes. We have now sequenced a direct, site-specific rearrangement between the δRec element and a pseudo Jα gene in a human leukemic stem-cell line. Putative 'N-sequence' addition was noted at the site of recombination, suggesting that this even occurred at the time when the enzyme(s) involved in N-region addition were active in this cell. This provides support for the view that deletion of the TCR-δ locus is required before rearrangement of the TCR-α chain genes.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalJournal of Experimental Medicine
Volume170
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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