Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects

James J. Nordlund, John Kirkwood, Bernadette M. Forget, Adrianna Scheibner, Daniel Albert, Emmanuel Lemer, G. W. Milton

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

We examined 296 patients with a history of melanoma and 145 controls for the presence of atypical (dysplastic) nevi. We found that 34% of patients with melanoma and 7% of controls had clinically atypical (dysplastic) nevi. Patients and controls with atypical (dysplastic) nevi had more nevi than the subjects without. The number of nevi varies negatively and significantly with age (r = -0.37, P < 0.001). Ten % of patients and controls had hypopigmented halos around one or more nevi. Both patients and comparison subjects with atypical (dysplastic) nevi tended to have this subtle variant of halo nevi more often than those without (r = 0.17, P < 0.01). The number of nevi on the irides of melanoma patients was greater than that in the comparison group. The results of this study suggest that patients with a melanoma exhibit more commonly cutaneous and ocular pigmentary lesions than comparison subjects without a melanoma.

Original languageEnglish (US)
Pages (from-to)1855-1861
Number of pages7
JournalCancer Research
Volume45
Issue number4
StatePublished - Apr 1 1985
Externally publishedYes

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Dysplastic Nevus Syndrome
Melanoma
Demography
Nevus
Halo Nevi
Iris
Skin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nordlund, J. J., Kirkwood, J., Forget, B. M., Scheibner, A., Albert, D., Lemer, E., & Milton, G. W. (1985). Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects. Cancer Research, 45(4), 1855-1861.

Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects. / Nordlund, James J.; Kirkwood, John; Forget, Bernadette M.; Scheibner, Adrianna; Albert, Daniel; Lemer, Emmanuel; Milton, G. W.

In: Cancer Research, Vol. 45, No. 4, 01.04.1985, p. 1855-1861.

Research output: Contribution to journalArticle

Nordlund, JJ, Kirkwood, J, Forget, BM, Scheibner, A, Albert, D, Lemer, E & Milton, GW 1985, 'Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects', Cancer Research, vol. 45, no. 4, pp. 1855-1861.
Nordlund JJ, Kirkwood J, Forget BM, Scheibner A, Albert D, Lemer E et al. Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects. Cancer Research. 1985 Apr 1;45(4):1855-1861.
Nordlund, James J. ; Kirkwood, John ; Forget, Bernadette M. ; Scheibner, Adrianna ; Albert, Daniel ; Lemer, Emmanuel ; Milton, G. W. / Demographic Study of Clinically Atypical (Dysplastic) Nevi in Patients with Melanoma and Comparison Subjects. In: Cancer Research. 1985 ; Vol. 45, No. 4. pp. 1855-1861.
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