Dementia in down’s syndrome: Cerebral glucose utilization, neuropsychological assessment, and neuropathology

M. B. Schapiro, M. J. Ball, C. L. Grady, J. V. Haxby, Jeffrey Kaye, S. I. Rapoport

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down’s syndrome (DS) and autopsy-confirmed Alzheimer’s disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and personality change. CMRglc in the subject was compared with the mean obtained in 13 healthy younger DS subjects, aged 19 to 33 years. Test scores of general intelligence, visuospatial ability, language, and memory function showed poorer performance in the older subject compared with the younger group. Mean hemispheric CMRglc in the older DS subject was 28% less than in the young DS group, and marked hypometabolism was evident in parietal and temporal lobe association cortices. At autopsy, extensive neuropathology was noted, especially in the parietal and temporal cortical regions, more so than reported in DS subjects without documented dementia. This study is the first complete assessment of cerebral metabolism, neuropsychological competence, and neuropathology in a DS subject with a documented course of dementia, and demonstrates the superimposition of Alzheimer type dementia on previous mental retardation.

Original languageEnglish (US)
Pages (from-to)938-942
Number of pages5
JournalNeurology
Volume38
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Down Syndrome
Dementia
Glucose
Temporal Lobe
Autopsy
Alzheimer Disease
Parietal Lobe
Aptitude
Fluorodeoxyglucose F18
Memory Disorders
Neuropathology
Intelligence
Intellectual Disability
Positron-Emission Tomography
Mental Competency
Personality
Language

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schapiro, M. B., Ball, M. J., Grady, C. L., Haxby, J. V., Kaye, J., & Rapoport, S. I. (1988). Dementia in down’s syndrome: Cerebral glucose utilization, neuropsychological assessment, and neuropathology. Neurology, 38(6), 938-942.

Dementia in down’s syndrome : Cerebral glucose utilization, neuropsychological assessment, and neuropathology. / Schapiro, M. B.; Ball, M. J.; Grady, C. L.; Haxby, J. V.; Kaye, Jeffrey; Rapoport, S. I.

In: Neurology, Vol. 38, No. 6, 1988, p. 938-942.

Research output: Contribution to journalArticle

Schapiro, MB, Ball, MJ, Grady, CL, Haxby, JV, Kaye, J & Rapoport, SI 1988, 'Dementia in down’s syndrome: Cerebral glucose utilization, neuropsychological assessment, and neuropathology', Neurology, vol. 38, no. 6, pp. 938-942.
Schapiro, M. B. ; Ball, M. J. ; Grady, C. L. ; Haxby, J. V. ; Kaye, Jeffrey ; Rapoport, S. I. / Dementia in down’s syndrome : Cerebral glucose utilization, neuropsychological assessment, and neuropathology. In: Neurology. 1988 ; Vol. 38, No. 6. pp. 938-942.
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