Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

Sophie Nyberg, N. Joan Abbott, Xiaorui Shi, Peter S. Steyger, Alain Dabdoub

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Permanent hearing loss affects more than 5% of the world’s population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the cochlea and vestibular system of the inner ear is complicated by their inaccessible location. Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier at the luminal surface of inner ear capillaries restricts entry of most blood-borne compounds into inner ear tissues. Here, we compare the blood-labyrinth barrier to the blood-brain barrier, discuss invasive intratympanic and intracochlear drug delivery methods, and evaluate noninvasive strategies for drug delivery to the inner ear.

Original languageEnglish (US)
Article numbereaao0935
JournalScience translational medicine
Volume11
Issue number482
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Medicine(all)

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