Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Benner, Thomas Hielscher, Till Milde, Marc Remke, David T.W. Jones, Paul A. Northcott, Livia Garzia, Kelsey C. Bertrand, Andrea Wittmann, Yuan Yao, Stephen S. Roberts, Luca Massimi, Tim Van Meter, William A. WeissNalin Gupta, Wiesia Grajkowska, Boleslaw Lach, Yoon Jae Cho, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Gary D. Bader, Cynthia E. Hawkins, Uri Tabori, Abhijit Guha, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor, Stefan M. Pfister

Research output: Contribution to journalArticle

300 Scopus citations

Abstract

Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.

Original languageEnglish (US)
Pages (from-to)143-157
Number of pages15
JournalCancer Cell
Volume20
Issue number2
DOIs
StatePublished - Aug 16 2011

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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    Witt, H., Mack, S. C., Ryzhova, M., Bender, S., Sill, M., Isserlin, R., Benner, A., Hielscher, T., Milde, T., Remke, M., Jones, D. T. W., Northcott, P. A., Garzia, L., Bertrand, K. C., Wittmann, A., Yao, Y., Roberts, S. S., Massimi, L., Van Meter, T., ... Pfister, S. M. (2011). Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma. Cancer Cell, 20(2), 143-157. https://doi.org/10.1016/j.ccr.2011.07.007