@article{6f7e8787defd46768b9a356b74aeb8ac,
title = "Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma",
abstract = "Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.",
author = "Hendrik Witt and Mack, {Stephen C.} and Marina Ryzhova and Sebastian Bender and Martin Sill and Ruth Isserlin and Axel Benner and Thomas Hielscher and Till Milde and Marc Remke and Jones, {David T.W.} and Northcott, {Paul A.} and Livia Garzia and Bertrand, {Kelsey C.} and Andrea Wittmann and Yuan Yao and Roberts, {Stephen S.} and Luca Massimi and {Van Meter}, Tim and Weiss, {William A.} and Nalin Gupta and Wiesia Grajkowska and Boleslaw Lach and Cho, {Yoon Jae} and {von Deimling}, Andreas and Kulozik, {Andreas E.} and Olaf Witt and Bader, {Gary D.} and Hawkins, {Cynthia E.} and Uri Tabori and Abhijit Guha and Rutka, {James T.} and Peter Lichter and Andrey Korshunov and Taylor, {Michael D.} and Pfister, {Stefan M.}",
note = "Funding Information: We thank Stephanie Riester, Stephanie Willrett and Anna Sch{\"o}ttler for their excellent technical assistance. We also thank Dr. Jill Mesirov and Dr. Pablo Tamayo for their bioinformatics assistance. Research in the Pfister laboratory is funded by the Sander-Stiftung, “Tour der Hoffnung,” and the Fritz-Lambert Preis to S.P. and A.K. M.D.T. is supported by a Clinician Scientist Phase II award from the Canadian Institutes of Health Research (CIHR). S.M. is supported by the CIHR Vanier Scholarship. Research in the Taylor laboratory is supported by the Pediatric Brain Tumor Foundation, the Canadian Institutes of Health Research, and the C.R. Younger Foundation. We thank Susan Archer for assistance with technical writing. ",
year = "2011",
month = aug,
day = "16",
doi = "10.1016/j.ccr.2011.07.007",
language = "English (US)",
volume = "20",
pages = "143--157",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}