Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo

Ting Xu, Arnaud Falchier, Elinor Sullivan, Gary Linn, Julian S.B. Ramirez, Deborah Ross, Eric Feczko, Alexander Opitz, Jennifer Bagley, Darrick Sturgeon, Eric Earl, Oscar Miranda Dominguez, Anders Perrone, R. Cameron Craddock, Charles E. Schroeder, Stan Colcombe, Damien Fair, Michael P. Milham

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides the opportunity to overcome critical barriers in translational research. Here, we establish the data requirements for achieving reproducible and internally valid parcellations in individuals. We demonstrate that functional boundaries serve as a functional fingerprint of the individual animals and can be achieved under anesthesia or awake conditions (rest, naturalistic viewing), though differences between awake and anesthetized states precluded the detection of individual differences across states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivity for higher-order association areas, as well as visual and motor cortex. These results establish feasibility and data requirements for the generation of reproducible individual-specific parcellations in NHPs, provide insights into the impact of scan state, and motivate efforts toward harmonizing protocols. Noninvasive fMRI in macaques is an essential tool in translation research. Xu et al. establish the individual functional parcellation of the macaque cortex and demonstrate that brain organization is unique, reproducible, and valid, serving as a fingerprint for an individual macaque.

Original languageEnglish (US)
Pages (from-to)429-441
Number of pages13
JournalCell Reports
Volume23
Issue number2
DOIs
StatePublished - Apr 10 2018

Fingerprint

Macaca
Brain
Dermatoglyphics
Organizations
Histology
Magnetic Resonance Imaging
Animals
Translational Medical Research
Motor Cortex
Visual Cortex
Individuality
Primates
Anesthesia
Research

Keywords

  • cortical areas
  • functional connectivity
  • gradient
  • macaque
  • parcellation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Xu, T., Falchier, A., Sullivan, E., Linn, G., Ramirez, J. S. B., Ross, D., ... Milham, M. P. (2018). Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Reports, 23(2), 429-441. https://doi.org/10.1016/j.celrep.2018.03.049

Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. / Xu, Ting; Falchier, Arnaud; Sullivan, Elinor; Linn, Gary; Ramirez, Julian S.B.; Ross, Deborah; Feczko, Eric; Opitz, Alexander; Bagley, Jennifer; Sturgeon, Darrick; Earl, Eric; Miranda Dominguez, Oscar; Perrone, Anders; Craddock, R. Cameron; Schroeder, Charles E.; Colcombe, Stan; Fair, Damien; Milham, Michael P.

In: Cell Reports, Vol. 23, No. 2, 10.04.2018, p. 429-441.

Research output: Contribution to journalArticle

Xu, T, Falchier, A, Sullivan, E, Linn, G, Ramirez, JSB, Ross, D, Feczko, E, Opitz, A, Bagley, J, Sturgeon, D, Earl, E, Miranda Dominguez, O, Perrone, A, Craddock, RC, Schroeder, CE, Colcombe, S, Fair, D & Milham, MP 2018, 'Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo', Cell Reports, vol. 23, no. 2, pp. 429-441. https://doi.org/10.1016/j.celrep.2018.03.049
Xu, Ting ; Falchier, Arnaud ; Sullivan, Elinor ; Linn, Gary ; Ramirez, Julian S.B. ; Ross, Deborah ; Feczko, Eric ; Opitz, Alexander ; Bagley, Jennifer ; Sturgeon, Darrick ; Earl, Eric ; Miranda Dominguez, Oscar ; Perrone, Anders ; Craddock, R. Cameron ; Schroeder, Charles E. ; Colcombe, Stan ; Fair, Damien ; Milham, Michael P. / Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. In: Cell Reports. 2018 ; Vol. 23, No. 2. pp. 429-441.
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