Deletions and microdeletions of 22q11.2 in velo-cardio-facial syndrome

D. A. Driscoll, N. B. Spinner, M. L. Budarf, D. M. McDonald-McGinn, E. H. Zackai, R. B. Goldberg, R. J. Shprintzen, H. M. Saal, J. Zonana, M. C. Jones, J. T. Mascarello, B. S. Emanuel

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

Velo-cardio-facial syndrome (VCFS), an autosomal dominant disorder, is characterized by cleft palate, cardiac defects, learning disabilities and a typical facial appearance. Less frequently, VCFS patients have manifestations of the DiGeorge complex (DGC) including hypocalcemia, hypoplastic or absent lymphoid tissue and T-cell deficiency suggesting that these 2 conditions share a common pathogenesis. Here, we report the results of cytogenetic and molecular studies of 15 VCFS patients. High - resolution banding techniques detected an interstitial deletion of 22q11.21-q11.23 in 3 patients. The remaining 12 patients had apparently normal chromosomes. Molecular analysis with probes from the DiGeorge Chromosome Region (DGCR) within 22q11 detected DNA deletions in 14 of 15 patients. In 2 families, deletions were detected in the affected parent as well as the propositus suggesting that the autosomal dominant transmission of VCFS is due to segregation of a deletion. Deletions of the same loci previously shown to be deleted in patients with DGC explains the overlapping phenotype of VCFS and the DGC and supports the hypothesis that the cause of these two disorders is the same.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume44
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • 22q11 microdeletions
  • chromosome 22q11 interstitial deletions
  • segmentally aneusomic disorder

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Driscoll, D. A., Spinner, N. B., Budarf, M. L., McDonald-McGinn, D. M., Zackai, E. H., Goldberg, R. B., Shprintzen, R. J., Saal, H. M., Zonana, J., Jones, M. C., Mascarello, J. T., & Emanuel, B. S. (1992). Deletions and microdeletions of 22q11.2 in velo-cardio-facial syndrome. American Journal of Medical Genetics, 44(2), 261-268. https://doi.org/10.1002/ajmg.1320440237