Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest

Navid Darouian, Kumar Narayanan, Aapo L. Aro, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated. Objective To evaluate the association of DID and SCA in the community. Methods In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA. Archived ECGs (closest and unrelated to SCA event for cases) were evaluated for the presence of DID, defined as ≥0.05 second in leads V5 or V6. Left ventricular (LV) mass and function were evaluated from archived echocardiograms. Results SCA cases (n = 272, 68.7 ± 14.6 years, 63.6% male) as compared to controls (n = 351, 67.6 ± 11.4 years, 63.3% male) were more likely to have DID on ECG (28.3% vs 17.1%, P =.001). DID was associated with increased SCA odds (odds ratio [OR] 1.92; 95% confidence interval [CI] 1.31-2.81; P =.001), but showed poor correlation with LV mass and echocardiographic LVH (kappa 0.13). In multivariate analysis adjusted for clinical and ECG markers, reduced LV ejection fraction, and echocardiographic LVH, DID remained an independent predictor of SCA (OR 1.82; 95% CI 1.12-2.97; P =.016). Additionally, in a sensitivity analysis restricted to narrow QRS, DID and ECG LVH by voltage were each independently associated with SCA risk. Conclusion DID was associated with increased SCA risk independent of echocardiographic LVH, ECG LVH, and reduced LV ejection fraction, potentially reflecting unique electrical remodeling that warrants further investigation.

Original languageEnglish (US)
Pages (from-to)927-932
Number of pages6
JournalHeart Rhythm
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Sudden Cardiac Death
Left Ventricular Hypertrophy
Electrocardiography
Stroke Volume
Odds Ratio
Atrial Remodeling
Confidence Intervals
Sudden Death
Left Ventricular Function
Multivariate Analysis
Biomarkers

Keywords

  • Arrhythmia
  • Electrocardiography
  • Intrinsicoid deflection
  • Left ventricular hypertrophy
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Darouian, N., Narayanan, K., Aro, A. L., Reinier, K., Uy-Evanado, A., Teodorescu, C., ... Chugh, S. S. (2016). Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest. Heart Rhythm, 13(4), 927-932. https://doi.org/10.1016/j.hrthm.2015.12.022

Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest. / Darouian, Navid; Narayanan, Kumar; Aro, Aapo L.; Reinier, Kyndaron; Uy-Evanado, Audrey; Teodorescu, Carmen; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S.

In: Heart Rhythm, Vol. 13, No. 4, 01.04.2016, p. 927-932.

Research output: Contribution to journalArticle

Darouian, N, Narayanan, K, Aro, AL, Reinier, K, Uy-Evanado, A, Teodorescu, C, Gunson, K, Jui, J & Chugh, SS 2016, 'Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest', Heart Rhythm, vol. 13, no. 4, pp. 927-932. https://doi.org/10.1016/j.hrthm.2015.12.022
Darouian N, Narayanan K, Aro AL, Reinier K, Uy-Evanado A, Teodorescu C et al. Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest. Heart Rhythm. 2016 Apr 1;13(4):927-932. https://doi.org/10.1016/j.hrthm.2015.12.022
Darouian, Navid ; Narayanan, Kumar ; Aro, Aapo L. ; Reinier, Kyndaron ; Uy-Evanado, Audrey ; Teodorescu, Carmen ; Gunson, Karen ; Jui, Jonathan ; Chugh, Sumeet S. / Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest. In: Heart Rhythm. 2016 ; Vol. 13, No. 4. pp. 927-932.
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abstract = "Background Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated. Objective To evaluate the association of DID and SCA in the community. Methods In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA. Archived ECGs (closest and unrelated to SCA event for cases) were evaluated for the presence of DID, defined as ≥0.05 second in leads V5 or V6. Left ventricular (LV) mass and function were evaluated from archived echocardiograms. Results SCA cases (n = 272, 68.7 ± 14.6 years, 63.6{\%} male) as compared to controls (n = 351, 67.6 ± 11.4 years, 63.3{\%} male) were more likely to have DID on ECG (28.3{\%} vs 17.1{\%}, P =.001). DID was associated with increased SCA odds (odds ratio [OR] 1.92; 95{\%} confidence interval [CI] 1.31-2.81; P =.001), but showed poor correlation with LV mass and echocardiographic LVH (kappa 0.13). In multivariate analysis adjusted for clinical and ECG markers, reduced LV ejection fraction, and echocardiographic LVH, DID remained an independent predictor of SCA (OR 1.82; 95{\%} CI 1.12-2.97; P =.016). Additionally, in a sensitivity analysis restricted to narrow QRS, DID and ECG LVH by voltage were each independently associated with SCA risk. Conclusion DID was associated with increased SCA risk independent of echocardiographic LVH, ECG LVH, and reduced LV ejection fraction, potentially reflecting unique electrical remodeling that warrants further investigation.",
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T1 - Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest

AU - Darouian, Navid

AU - Narayanan, Kumar

AU - Aro, Aapo L.

AU - Reinier, Kyndaron

AU - Uy-Evanado, Audrey

AU - Teodorescu, Carmen

AU - Gunson, Karen

AU - Jui, Jonathan

AU - Chugh, Sumeet S.

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N2 - Background Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated. Objective To evaluate the association of DID and SCA in the community. Methods In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA. Archived ECGs (closest and unrelated to SCA event for cases) were evaluated for the presence of DID, defined as ≥0.05 second in leads V5 or V6. Left ventricular (LV) mass and function were evaluated from archived echocardiograms. Results SCA cases (n = 272, 68.7 ± 14.6 years, 63.6% male) as compared to controls (n = 351, 67.6 ± 11.4 years, 63.3% male) were more likely to have DID on ECG (28.3% vs 17.1%, P =.001). DID was associated with increased SCA odds (odds ratio [OR] 1.92; 95% confidence interval [CI] 1.31-2.81; P =.001), but showed poor correlation with LV mass and echocardiographic LVH (kappa 0.13). In multivariate analysis adjusted for clinical and ECG markers, reduced LV ejection fraction, and echocardiographic LVH, DID remained an independent predictor of SCA (OR 1.82; 95% CI 1.12-2.97; P =.016). Additionally, in a sensitivity analysis restricted to narrow QRS, DID and ECG LVH by voltage were each independently associated with SCA risk. Conclusion DID was associated with increased SCA risk independent of echocardiographic LVH, ECG LVH, and reduced LV ejection fraction, potentially reflecting unique electrical remodeling that warrants further investigation.

AB - Background Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated. Objective To evaluate the association of DID and SCA in the community. Methods In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA. Archived ECGs (closest and unrelated to SCA event for cases) were evaluated for the presence of DID, defined as ≥0.05 second in leads V5 or V6. Left ventricular (LV) mass and function were evaluated from archived echocardiograms. Results SCA cases (n = 272, 68.7 ± 14.6 years, 63.6% male) as compared to controls (n = 351, 67.6 ± 11.4 years, 63.3% male) were more likely to have DID on ECG (28.3% vs 17.1%, P =.001). DID was associated with increased SCA odds (odds ratio [OR] 1.92; 95% confidence interval [CI] 1.31-2.81; P =.001), but showed poor correlation with LV mass and echocardiographic LVH (kappa 0.13). In multivariate analysis adjusted for clinical and ECG markers, reduced LV ejection fraction, and echocardiographic LVH, DID remained an independent predictor of SCA (OR 1.82; 95% CI 1.12-2.97; P =.016). Additionally, in a sensitivity analysis restricted to narrow QRS, DID and ECG LVH by voltage were each independently associated with SCA risk. Conclusion DID was associated with increased SCA risk independent of echocardiographic LVH, ECG LVH, and reduced LV ejection fraction, potentially reflecting unique electrical remodeling that warrants further investigation.

KW - Arrhythmia

KW - Electrocardiography

KW - Intrinsicoid deflection

KW - Left ventricular hypertrophy

KW - Sudden cardiac death

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