Delayed development of adult-generated granule cells in dentate gyrus

Linda S. Overstreet-Wadiche, Ae Soon L. Bensen, Gary L. Westbrook

Research output: Contribution to journalArticle

136 Scopus citations

Abstract

A substantial fraction of adult-generated granule cells in the dentate gyrus survive and integrate into the existing neuronal network. These newborn neurons must navigate the environment of the adult brain, a setting that is presumably less optimized for neuronal maturation compared with that in the developing brain. We used EGFP (enhanced green fluorescent protein) expression in newborn granule cells to compare the maturation of adult-generated granule cells to those generated in neonates. Labeled newborn granule cells had indistinguishable physiological properties in adults and neonates, indicating they were at the same functional stage. However, the maturation of adult-generated granule cells was slower than neonatal-generated granule cells. Depolarizing GABAergic network activity and transcription factor activation were reduced in adults relative to neonates, suggesting a role for neural activity in the maturation of newborn granule cells. Consistent with this idea, maturation was altered in mice lacking the GABA synthetic enzyme GAD65 (glutamic acid decarboxylase 65). Together, these results provide evidence that activity-dependent processes in the local environment influence the maturation of newborn granule cells.

Original languageEnglish (US)
Pages (from-to)2326-2334
Number of pages9
JournalJournal of Neuroscience
Volume26
Issue number8
DOIs
StatePublished - Feb 22 2006

Keywords

  • Activity dependent
  • Bromodeoxyuridine
  • Dentate gyrus
  • Depolarizing GABA
  • Development
  • GAD65
  • Giant depolarizing potential
  • Granule cell
  • Hippocampus
  • Neural stem cell
  • Neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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