Delayed Cutaneous Hypersensitivity and Lymphocyte Transformation: Dissociation in Atopic Dermatitis

Susan T. Elliott, Jon M. Hanifin

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Studies of cell mediated immunity (CMI) in atopic dermatitis have demonstrated various defects and frequently contradictory results. The true nature of immune dysfunction remains uncertain. We approached this question by concurrently examining two aspects of CMI: delayed cutaneous hypersensitivity and in vitro lymphocyte transformation. Responses were tested using the antigens Candida albicans and streptokinasestreptodornase (SKSD). Mean lymphocyte transformation was equal in atopic patients and controls, although a subgroup of severely dermatitic patients showed depressed responses. Cutaneous anergy was the rule in atopic patients (96% to candidin and 84% to SKSD). Although normal subjects showed good correlation between in vitro and cutaneous responses, atopic patients showed a significant lack of correlation. Many patients manifested cutaneous anergy in the face of normal lymphocyte transformation responses.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalArchives of dermatology
Volume115
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Dermatology

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