Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism

Megan M. Herting, Daniel Schwartz, Suzanne Mitchell, Bonnie Nagel

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Background: Youth with family history of alcohol abuse have a greater risk of developing an alcohol use disorder (AUD). Brain and behavior differences may underlie this increased vulnerability. The current study examined delay discounting behavior and white matter microstructure in youth at high risk for alcohol abuse, as determined by a family history of alcoholism (FH+), and youth without such family history (FH-). Methods: Thirty-three healthy youth (FH+ = 15, FH- = 18), ages 11 to 15 years, completed a delay discounting task and underwent diffusion tensor imaging. Tract-based spatial statistics (Smith et al., 2006), as well as follow-up region-of-interest analyses, were performed to compare fractional anisotropy (FA) between FH+ and FH- youth. Results: FH+ youth showed a trend toward increased discounting behavior and had significantly slower reaction times (RTs) on the delay discounting paradigm compared to FH- youth. Group differences in FA were seen in several white matter tracts. Furthermore, lower FA in the left inferior longitudinal fasciculus and the right optic radiation statistically mediated the relationship between FH status and slower RTs on the delay discounting task. Conclusions: Youth with a family history of substance abuse have disrupted white matter microstructure, which likely contributes to less efficient cortical processing and may act as an intrinsic risk factor contributing to an increased susceptibility of developing AUD. In addition, FHP youth showed a trend toward greater impulsive decision making, possibly representing an inherent personal characteristic that may facilitate substance use onset and abuse in high-risk youth.

Original languageEnglish (US)
Pages (from-to)1590-1602
Number of pages13
JournalAlcoholism: Clinical and Experimental Research
Volume34
Issue number9
DOIs
StatePublished - Sep 2010

Fingerprint

Alcoholism
Alcohols
Microstructure
Anisotropy
Diffusion tensor imaging
Intrinsic Factor
Optics
Brain
Decision making
Reaction Time
Statistics
Radiation
White Matter
Delay Discounting
Processing
Diffusion Tensor Imaging
Substance-Related Disorders
Decision Making

Keywords

  • Adolescence
  • Alcohol Abuse
  • Delay Discounting
  • Diffusion Tensor Imaging
  • Family History

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. / Herting, Megan M.; Schwartz, Daniel; Mitchell, Suzanne; Nagel, Bonnie.

In: Alcoholism: Clinical and Experimental Research, Vol. 34, No. 9, 09.2010, p. 1590-1602.

Research output: Contribution to journalArticle

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