The Wnt-1 transgenic system has provided a rich model for studying mammary tumorigenesis in the mouse. Crossing these animals to other transgenic animals and infecting them with MMTV have forcefully demonstrated the synergy between Wnt-1 and members of the Fgf family. Mammary tumors from Wnt-1 TG/p53-deficient mice present novel features: a less fibrotic histology, rapid kinetics of tumor formation, and increased genomic instability. Understanding the molecular basis for such phenotypes may provide insights into the behavior of human tumors, especially those in which p53 has been affected.
|Original language||English (US)|
|Number of pages||9|
|Journal||Cold Spring Harbor symposia on quantitative biology|
|State||Published - 1994|
ASJC Scopus subject areas
- Molecular Biology