Defining the steps in a multistep mouse model for mammary carcinogenesis

H. E. Varmus, L. A. Godley, S. Roy, I. C A Taylor, L. Yuschenkoff, Y. P. Shi -, D. Pinkel, Joe Gray, R. Pyle, C. M. Aldaz, A. Bradley, D. Medina, L. A. Donehower

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The Wnt-1 transgenic system has provided a rich model for studying mammary tumorigenesis in the mouse. Crossing these animals to other transgenic animals and infecting them with MMTV have forcefully demonstrated the synergy between Wnt-1 and members of the Fgf family. Mammary tumors from Wnt-1 TG/p53-deficient mice present novel features: a less fibrotic histology, rapid kinetics of tumor formation, and increased genomic instability. Understanding the molecular basis for such phenotypes may provide insights into the behavior of human tumors, especially those in which p53 has been affected.

Original languageEnglish (US)
Pages (from-to)491-499
Number of pages9
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume59
StatePublished - 1994
Externally publishedYes

Fingerprint

carcinogenesis
breasts
Tumors
Carcinogenesis
Breast
animal models
transgenic animals
Genetically Modified Animals
neoplasms
Genomic Instability
mammary neoplasms (animal)
mice
Animals
human behavior
histology
Neoplasms
Histology
genetically modified organisms
Breast Neoplasms
Phenotype

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Molecular Biology

Cite this

Varmus, H. E., Godley, L. A., Roy, S., Taylor, I. C. A., Yuschenkoff, L., Shi -, Y. P., ... Donehower, L. A. (1994). Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harbor Symposia on Quantitative Biology, 59, 491-499.

Defining the steps in a multistep mouse model for mammary carcinogenesis. / Varmus, H. E.; Godley, L. A.; Roy, S.; Taylor, I. C A; Yuschenkoff, L.; Shi -, Y. P.; Pinkel, D.; Gray, Joe; Pyle, R.; Aldaz, C. M.; Bradley, A.; Medina, D.; Donehower, L. A.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 59, 1994, p. 491-499.

Research output: Contribution to journalArticle

Varmus, HE, Godley, LA, Roy, S, Taylor, ICA, Yuschenkoff, L, Shi -, YP, Pinkel, D, Gray, J, Pyle, R, Aldaz, CM, Bradley, A, Medina, D & Donehower, LA 1994, 'Defining the steps in a multistep mouse model for mammary carcinogenesis', Cold Spring Harbor Symposia on Quantitative Biology, vol. 59, pp. 491-499.
Varmus HE, Godley LA, Roy S, Taylor ICA, Yuschenkoff L, Shi - YP et al. Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harbor Symposia on Quantitative Biology. 1994;59:491-499.
Varmus, H. E. ; Godley, L. A. ; Roy, S. ; Taylor, I. C A ; Yuschenkoff, L. ; Shi -, Y. P. ; Pinkel, D. ; Gray, Joe ; Pyle, R. ; Aldaz, C. M. ; Bradley, A. ; Medina, D. ; Donehower, L. A. / Defining the steps in a multistep mouse model for mammary carcinogenesis. In: Cold Spring Harbor Symposia on Quantitative Biology. 1994 ; Vol. 59. pp. 491-499.
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