Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2

Ching Chen, Tammy Martin, Susan Stevens, Marvin Rittenberg

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have investigated four secretion-deficient antibodies (Abs) derived from a panel of 46 mutant T15 anti-phosphocholine Abs, all of which have point mutations in the heavy chain (H) complementarity determining region 2 (CDR2). The level of secretion for these four Abs was

Original languageEnglish (US)
Pages (from-to)577-586
Number of pages10
JournalJournal of Experimental Medicine
Volume180
Issue number2
DOIs
StatePublished - Aug 1 1994

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Complementarity Determining Regions
Immunoglobulins
Mutation
Phosphorylcholine
Antibodies
Point Mutation
Anti-Idiotypic Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2. / Chen, Ching; Martin, Tammy; Stevens, Susan; Rittenberg, Marvin.

In: Journal of Experimental Medicine, Vol. 180, No. 2, 01.08.1994, p. 577-586.

Research output: Contribution to journalArticle

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