Defective bactericidal activity in myeloperoxidase-deficient human neutrophils

Robert I. Lehrer, Jon Hanifin, Martin J. Cline

Research output: Contribution to journalLetter

72 Scopus citations

Abstract

NORMAL human polymorphonuclear neutrophilic leucocytes (PMN) contain an abundance of myeloperoxidase, a lysosomal enzyme estimated to constitute between 2 and 5 per cent of the dry weight of the leucocytes1,2. Although the enzyme has been purified and characterized, its contribution to the cellular economy has not been clearly defined. Recent investigations have suggested it participates in bactericidal processes3,4.

Original languageEnglish (US)
Pages (from-to)78-79
Number of pages2
JournalNature
Volume223
Issue number5201
DOIs
StatePublished - Dec 1 1969

ASJC Scopus subject areas

  • General

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