Deep vein thrombosis treated with streptokinase or heparin: Follow-up of a randomized study

Herbert H. Common, Arthur J. Seaman, Josef Rösch, John M. Porter, Charles T. Dotter

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Twenty-seven patients with deep vein thrombosis whose primary therapy was randomized between streptokinase and heparin were reevaluated clinically and by ascending venography after a mean period of 7 months. Normal venograms were found in 6 (40%) of the streptokinase-treated patients and in 1 patient (8%) who had heparin therapy. Segmental valve preservation was found in 1 patient from each group. All patients with complete or partial valve preservation became asymptomatic. Vein re canalization without preservation of valves occurred in 18 patients: 8 (54%) of those on streptokinase, and 10 (83%) of those on heparin. At the time of follow-up, 11 of these 18 patients, including 8 who had had prior thrombosis, reported peripheral edema; the postphlebitic syndrome devel oped in 1. Factors favoring a good outcome of acute venous thrombosis were (1) no prior thrombotic disease, (2) localized thrombosis, and (3) prompt streptokinase therapy.

Original languageEnglish (US)
Pages (from-to)645-654
Number of pages10
JournalAngiology
Volume27
Issue number11
DOIs
StatePublished - Nov 1976

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Common, H. H., Seaman, A. J., Rösch, J., Porter, J. M., & Dotter, C. T. (1976). Deep vein thrombosis treated with streptokinase or heparin: Follow-up of a randomized study. Angiology, 27(11), 645-654. https://doi.org/10.1177/000331977602701105