Deep Neural Network Trained on Surface ECG Improves Diagnostic Accuracy of Prior Myocardial Infarction over Q Wave Analysis

Ozal Yildirim, Ulas B. Baloglu, Muhammed Talo, Prasanth Ganesan, Jagteshwar S. Tung, Guson Kang, James Tooley, Mahmood I. Alhusseini, Tina Baykaner, Paul J. Wang, Marco V. Perez, Larisa Tereshchenko, Sanjiv M. Narayan, Albert J. Rogers

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Clinical screening of myocardial infarction is important for preventative treatment and risk stratification in cardiology practice, however current detection by electrocardiogram Q-wave analysis provides only modest accuracy for assessing prior cardiac events. We set out to evaluate the ability of a deep neural network trained on the electrocardiogram to identify patients with clinical history of myocardial infarction. We assessed 608 patients at two academic centers with adjudicated history of myocardial infarction. Surface electrocardiograms were used to train a neural network-based model that classifies patients with and without a history of infarction. Endpoints were assessed by clinical record review and accuracy of the model was compared against the manual assessment of pathologic Q waves. The neural network outperformed the accuracy of pathologic Q waves (62%). In training, the model accuracy converged to >98%. Validation was performed by cross-validation (k=5) with validation accuracy 71 ± 5%. Receiver-operator characteristics analysis resulted in a c-statistic of 0.730. Deep learning of a 12-lead ECG can identify features of prior myocardial injury more accurately than clinical Q-wave analysis and may serve as a valuable clinical screening tool.

Original languageEnglish (US)
Title of host publication2021 Computing in Cardiology, CinC 2021
PublisherIEEE Computer Society
ISBN (Electronic)9781665479165
StatePublished - 2021
Externally publishedYes
Event2021 Computing in Cardiology, CinC 2021 - Brno, Czech Republic
Duration: Sep 13 2021Sep 15 2021

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


Conference2021 Computing in Cardiology, CinC 2021
Country/TerritoryCzech Republic

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine


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