Decreases in dopamine receptors but not in dopamine transporters in alcoholics

Nora D. Volkow, Gene Jack Wang, Joanna S. Fowler, Jean Logan, Robert Hitzemann, Yu Shin Ding, Naomi Pappas, Colleen Shea, Kathleen Piscani

Research output: Contribution to journalArticle

389 Citations (Scopus)

Abstract

It has been hypothesized that ethanol's actions on the dopamine (DA) system may participate in addiction. The purpose of this study was to evaluate the DA system in the brain of alcoholics. We evaluated 10 alcoholics and 17 nonalcoholics using positron emission tomography and [11C]raclopride to measure DA D2 receptors. In addition, in 5 of the alcoholics and 16 of the nonalcoholics, we also measured DA transporters with [11C]d-threo methylphenidate. The ratio of the distribution volumes in striatum to that in cerebellum, which corresponds to B(max)/K(d) + 1, was used as model parameter of DA D2 receptor and transporter availability. Dopamine D2 receptor availability (B(max)/K(d)) was significantly lower in alcoholics (2.1 ± 0.5) than in nonalcoholics (2.7 ± 0.6) (p <0.05) and was not correlated with days since last alcohol use. Alcoholics showed DA transporter values similar to those in nonalcoholics. The ratio of DA D2 receptor to transporter availability was significantly higher in nonalcoholics (1.4 ± 0.1) than in alcoholics (1.1 ± 0.1) (p <0.005). Alcoholics showed significant reductions in D2 receptors (postsynaptic marker) but not in DA transporter availability (presynaptic marker) when compared with nonalcoholics. Because D2 receptors in striatum are mainly localized in γ-aminobutyric acid (GABA) cells these results provide evidence of GABAergic involvement in the dopaminergic abnormalities seen in alcoholics.

Original languageEnglish (US)
Pages (from-to)1594-1598
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume20
Issue number9
StatePublished - 1996
Externally publishedYes

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Dopamine D2 Receptors
Dopamine Receptors
Alcoholics
Availability
Dopamine
Raclopride
Aminobutyrates
Methylphenidate
Positron emission tomography
gamma-Aminobutyric Acid
Brain
Ethanol
Alcohols
GABAergic Neurons
Positron-Emission Tomography
Cerebellum

Keywords

  • Addiction
  • Alcoholism
  • GABA Neurons
  • Positron Emission Tomography
  • Raclopride

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y. S., ... Piscani, K. (1996). Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcoholism: Clinical and Experimental Research, 20(9), 1594-1598.

Decreases in dopamine receptors but not in dopamine transporters in alcoholics. / Volkow, Nora D.; Wang, Gene Jack; Fowler, Joanna S.; Logan, Jean; Hitzemann, Robert; Ding, Yu Shin; Pappas, Naomi; Shea, Colleen; Piscani, Kathleen.

In: Alcoholism: Clinical and Experimental Research, Vol. 20, No. 9, 1996, p. 1594-1598.

Research output: Contribution to journalArticle

Volkow, ND, Wang, GJ, Fowler, JS, Logan, J, Hitzemann, R, Ding, YS, Pappas, N, Shea, C & Piscani, K 1996, 'Decreases in dopamine receptors but not in dopamine transporters in alcoholics', Alcoholism: Clinical and Experimental Research, vol. 20, no. 9, pp. 1594-1598.
Volkow, Nora D. ; Wang, Gene Jack ; Fowler, Joanna S. ; Logan, Jean ; Hitzemann, Robert ; Ding, Yu Shin ; Pappas, Naomi ; Shea, Colleen ; Piscani, Kathleen. / Decreases in dopamine receptors but not in dopamine transporters in alcoholics. In: Alcoholism: Clinical and Experimental Research. 1996 ; Vol. 20, No. 9. pp. 1594-1598.
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