Abstract
To determine whether chronic hypoxemia results in alterations in endocrine function that may contribute to growth failure, we measured growth hormone (GH), somatomedins (insulin-like growth factors I and II, IGF-I and IGF-2), hepatic growth hormone receptors, and circulating IGF-binding proteins IGFBP-3 and IGFBP-2 in 12 newborn lambs with surgically created pulmonic stenosis and atrial septal defect, and in 10 controls. During chronic hypoxemia (oxygen saturation of 60-74% for 2 wk), weight gain was 60% of control (hypoxemic, 135±20 vs. control, 216±26 g/d, P <0.02). IGF-I was decreased by 43% (hypoxemic 253.6±29.3 SE vs. control 448.0±75.5 ng/ml, P = 0.01), whereas GH was unchanged (19.9±5.1 vs. 11.9±3.0 ng/ml, NS). The increase in IGF-1 was associated with a decrease in IGFBP-3 (hypoxemic, 5.09±1.25 vs. control, 11.2±1.08 arbitrary absorbency units per mm (Au · mm), P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1128-1132 |
| Number of pages | 5 |
| Journal | Journal of Clinical Investigation |
| Volume | 89 |
| Issue number | 4 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Failure to thrive
- Hypoxia
- Somatomedins
ASJC Scopus subject areas
- Medicine(all)
Cite this
Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease. / Bernstein, Daniel; Jasper, Jeffrey R.; Rosenfeld, Ronald (Ron); Hintz, Raymond L.
In: Journal of Clinical Investigation, Vol. 89, No. 4, 1992, p. 1128-1132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease
AU - Bernstein, Daniel
AU - Jasper, Jeffrey R.
AU - Rosenfeld, Ronald (Ron)
AU - Hintz, Raymond L.
PY - 1992
Y1 - 1992
N2 - To determine whether chronic hypoxemia results in alterations in endocrine function that may contribute to growth failure, we measured growth hormone (GH), somatomedins (insulin-like growth factors I and II, IGF-I and IGF-2), hepatic growth hormone receptors, and circulating IGF-binding proteins IGFBP-3 and IGFBP-2 in 12 newborn lambs with surgically created pulmonic stenosis and atrial septal defect, and in 10 controls. During chronic hypoxemia (oxygen saturation of 60-74% for 2 wk), weight gain was 60% of control (hypoxemic, 135±20 vs. control, 216±26 g/d, P <0.02). IGF-I was decreased by 43% (hypoxemic 253.6±29.3 SE vs. control 448.0±75.5 ng/ml, P = 0.01), whereas GH was unchanged (19.9±5.1 vs. 11.9±3.0 ng/ml, NS). The increase in IGF-1 was associated with a decrease in IGFBP-3 (hypoxemic, 5.09±1.25 vs. control, 11.2±1.08 arbitrary absorbency units per mm (Au · mm), P
AB - To determine whether chronic hypoxemia results in alterations in endocrine function that may contribute to growth failure, we measured growth hormone (GH), somatomedins (insulin-like growth factors I and II, IGF-I and IGF-2), hepatic growth hormone receptors, and circulating IGF-binding proteins IGFBP-3 and IGFBP-2 in 12 newborn lambs with surgically created pulmonic stenosis and atrial septal defect, and in 10 controls. During chronic hypoxemia (oxygen saturation of 60-74% for 2 wk), weight gain was 60% of control (hypoxemic, 135±20 vs. control, 216±26 g/d, P <0.02). IGF-I was decreased by 43% (hypoxemic 253.6±29.3 SE vs. control 448.0±75.5 ng/ml, P = 0.01), whereas GH was unchanged (19.9±5.1 vs. 11.9±3.0 ng/ml, NS). The increase in IGF-1 was associated with a decrease in IGFBP-3 (hypoxemic, 5.09±1.25 vs. control, 11.2±1.08 arbitrary absorbency units per mm (Au · mm), P
KW - Failure to thrive
KW - Hypoxia
KW - Somatomedins
UR - http://www.scopus.com/inward/record.url?scp=0026776540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026776540&partnerID=8YFLogxK
M3 - Article
C2 - 1372914
AN - SCOPUS:0026776540
VL - 89
SP - 1128
EP - 1132
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 4
ER -