Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease

Daniel Bernstein, Jeffrey R. Jasper, Ronald (Ron) Rosenfeld, Raymond L. Hintz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To determine whether chronic hypoxemia results in alterations in endocrine function that may contribute to growth failure, we measured growth hormone (GH), somatomedins (insulin-like growth factors I and II, IGF-I and IGF-2), hepatic growth hormone receptors, and circulating IGF-binding proteins IGFBP-3 and IGFBP-2 in 12 newborn lambs with surgically created pulmonic stenosis and atrial septal defect, and in 10 controls. During chronic hypoxemia (oxygen saturation of 60-74% for 2 wk), weight gain was 60% of control (hypoxemic, 135±20 vs. control, 216±26 g/d, P <0.02). IGF-I was decreased by 43% (hypoxemic 253.6±29.3 SE vs. control 448.0±75.5 ng/ml, P = 0.01), whereas GH was unchanged (19.9±5.1 vs. 11.9±3.0 ng/ml, NS). The increase in IGF-1 was associated with a decrease in IGFBP-3 (hypoxemic, 5.09±1.25 vs. control, 11.2±1.08 arbitrary absorbency units per mm (Au · mm), P

Original languageEnglish (US)
Pages (from-to)1128-1132
Number of pages5
JournalJournal of Clinical Investigation
Volume89
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 3
Heart Diseases
Insulin-Like Growth Factor II
Growth
Serum
Growth Hormone
Insulin-Like Growth Factor Binding Protein 2
Somatotropin Receptors
Pulmonary Valve Stenosis
Atrial Heart Septal Defects
Somatomedins
Weight Gain
Oxygen
Liver
Hypoxia

Keywords

  • Failure to thrive
  • Hypoxia
  • Somatomedins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease. / Bernstein, Daniel; Jasper, Jeffrey R.; Rosenfeld, Ronald (Ron); Hintz, Raymond L.

In: Journal of Clinical Investigation, Vol. 89, No. 4, 1992, p. 1128-1132.

Research output: Contribution to journalArticle

Bernstein, Daniel ; Jasper, Jeffrey R. ; Rosenfeld, Ronald (Ron) ; Hintz, Raymond L. / Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease. In: Journal of Clinical Investigation. 1992 ; Vol. 89, No. 4. pp. 1128-1132.
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