Decreased respiratory compliance in infants less than or equal to 32 weeks' gestation, delivered more than 7 days after antenatal steroid therapy

Cynthia (Cindy) McEvoy, Diane Schilling, Patricia Spitale, Dawn Peters, Jean O'Malley, Manuel Durand

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVES. Our objective was to compare the pulmonary function (respiratory compliance) of infants who were ≤32 weeks' gestation and delivered >7 days after a single course of antenatal steroids versus infants who were delivered 1 to 7 days after a single course of antenatal steroids. METHODS. A prospective cohort study of respiratory system compliance was conducted of infants ≤32 weeks' gestation within 72 hours of life and before surfactant therapy if needed. The study (remote) group was composed of infants who were treated with antenatal steroids 14 days (n = 18) before delivery. CONCLUSIONS. Infants who were ≤32 weeks' gestation and remotely treated with antenatal steroids (average 21 days) had a significantly lower respiratory compliance compared with matched infants who were ideally treated with antenatal steroids. We speculate that the lower respiratory system compliance may reflect the dissipation of beneficial effects of antenatal steroids on pulmonary function when delivery occurs >7 days after therapy and particularly when therapy is >14 days before delivery.

Original languageEnglish (US)
JournalPediatrics
Volume121
Issue number5
DOIs
StatePublished - May 2008

Fingerprint

Compliance
Steroids
Pregnancy
Respiratory System
Therapeutics
Lung
Surface-Active Agents
Cohort Studies
Prospective Studies

Keywords

  • Antenatal corticosteroids
  • Betamethasone
  • Premature infants
  • Pulmonary function
  • Respiratory compliance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Decreased respiratory compliance in infants less than or equal to 32 weeks' gestation, delivered more than 7 days after antenatal steroid therapy. / McEvoy, Cynthia (Cindy); Schilling, Diane; Spitale, Patricia; Peters, Dawn; O'Malley, Jean; Durand, Manuel.

In: Pediatrics, Vol. 121, No. 5, 05.2008.

Research output: Contribution to journalArticle

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AU - Peters, Dawn

AU - O'Malley, Jean

AU - Durand, Manuel

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AB - OBJECTIVES. Our objective was to compare the pulmonary function (respiratory compliance) of infants who were ≤32 weeks' gestation and delivered >7 days after a single course of antenatal steroids versus infants who were delivered 1 to 7 days after a single course of antenatal steroids. METHODS. A prospective cohort study of respiratory system compliance was conducted of infants ≤32 weeks' gestation within 72 hours of life and before surfactant therapy if needed. The study (remote) group was composed of infants who were treated with antenatal steroids 14 days (n = 18) before delivery. CONCLUSIONS. Infants who were ≤32 weeks' gestation and remotely treated with antenatal steroids (average 21 days) had a significantly lower respiratory compliance compared with matched infants who were ideally treated with antenatal steroids. We speculate that the lower respiratory system compliance may reflect the dissipation of beneficial effects of antenatal steroids on pulmonary function when delivery occurs >7 days after therapy and particularly when therapy is >14 days before delivery.

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