Objective: To quantitate gelsolin concentrations in serum of patients with a variety of conditions involving actin release into the circulation. Design: Prospective evaluation of sera on consecutive patients. Setting: Metropolitan county hospital. Patients: Ninety hospital patients with a variety of well-characterized diseases. Interventions: None. Measurements and Main Results: Sera were studied from patients with acute liver failure (n = 18), chronic hepatitis (n = 17), cirrhosis or varying etiology (n = 17), pancreatitis (n = 10), acute myocardial infarction (n = 10), myonecrosis due either to polymyositis or crush injuries (n = 12), and septic shock (n = 6); results were compared with sara from healthy individuals (n = 25). Gelsolin was quantified by Western blotting with monoclonal antigelsolin and laser densitometry. Significant reductions in mean gelsolin concentrations compared with healthy controls were observed in patients with acute liver failure (47%), myocardial infarction (69%), sepals (51%), and myonecrosis (66%). An inverse correlation was observed between gelsolin concentration and severity of illness, as indicated by the magnitude of serum enzyme concentrations. Conclusions: Gelsolin depletion occurs in a variety of tissue injury syndromes. Depletion of actin-scavenger capacity in the presence of continued actin release may affect outcome in situations of severe organ damage.
- actin-scavenger system
- acute liver failure
- multiple organ dysfunction syndrome
- myocardial infarction
- septic shock
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine