Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis

Eric Suhler, Weng Lin, Helen L. Yin, William M. Lee

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Objective: To quantitate gelsolin concentrations in serum of patients with a variety of conditions involving actin release into the circulation. Design: Prospective evaluation of sera on consecutive patients. Setting: Metropolitan county hospital. Patients: Ninety hospital patients with a variety of well-characterized diseases. Interventions: None. Measurements and Main Results: Sera were studied from patients with acute liver failure (n = 18), chronic hepatitis (n = 17), cirrhosis or varying etiology (n = 17), pancreatitis (n = 10), acute myocardial infarction (n = 10), myonecrosis due either to polymyositis or crush injuries (n = 12), and septic shock (n = 6); results were compared with sara from healthy individuals (n = 25). Gelsolin was quantified by Western blotting with monoclonal antigelsolin and laser densitometry. Significant reductions in mean gelsolin concentrations compared with healthy controls were observed in patients with acute liver failure (47%), myocardial infarction (69%), sepals (51%), and myonecrosis (66%). An inverse correlation was observed between gelsolin concentration and severity of illness, as indicated by the magnitude of serum enzyme concentrations. Conclusions: Gelsolin depletion occurs in a variety of tissue injury syndromes. Depletion of actin-scavenger capacity in the presence of continued actin release may affect outcome in situations of severe organ damage.

Original languageEnglish (US)
Pages (from-to)594-598
Number of pages5
JournalCritical care medicine
Volume25
Issue number4
DOIs
StatePublished - Apr 1997

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Keywords

  • actin
  • actin-scavenger system
  • acute liver failure
  • cirrhosis
  • gelsolin
  • multiple organ dysfunction syndrome
  • myocardial infarction
  • myonecrosis
  • pancreatitis
  • septic shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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