Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin

Giancarlo Colombo, Carl Hansen, Paula L. Hoffman, Kathleen A. Grant

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalPhysiology and Behavior
Volume52
Issue number4
DOIs
StatePublished - Oct 1992
Externally publishedYes

Keywords

  • Acquisition
  • Delayed alternation
  • Food-reinforcement
  • M520 strain
  • Memory
  • T-maze
  • Vasopressin
  • Vasopressin-deficient rats

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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