Abstract
Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 827-830 |
| Number of pages | 4 |
| Journal | Physiology and Behavior |
| Volume | 52 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Acquisition
- Delayed alternation
- Food-reinforcement
- M520 strain
- Memory
- T-maze
- Vasopressin
- Vasopressin-deficient rats
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience
Cite this
Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin. / Colombo, Giancarlo; Hansen, Carl; Hoffman, Paula L.; Grant, Kathleen (Kathy).
In: Physiology and Behavior, Vol. 52, No. 4, 1992, p. 827-830.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin
AU - Colombo, Giancarlo
AU - Hansen, Carl
AU - Hoffman, Paula L.
AU - Grant, Kathleen (Kathy)
PY - 1992
Y1 - 1992
N2 - Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.
AB - Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.
KW - Acquisition
KW - Delayed alternation
KW - Food-reinforcement
KW - M520 strain
KW - Memory
KW - T-maze
KW - Vasopressin
KW - Vasopressin-deficient rats
UR - http://www.scopus.com/inward/record.url?scp=0026666548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026666548&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(92)90422-X
DO - 10.1016/0031-9384(92)90422-X
M3 - Article
C2 - 1409961
AN - SCOPUS:0026666548
VL - 52
SP - 827
EP - 830
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 4
ER -