Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin

Giancarlo Colombo, Carl Hansen, Paula L. Hoffman, Kathleen A. Grant

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    Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.

    Original languageEnglish (US)
    Pages (from-to)827-830
    Number of pages4
    JournalPhysiology and Behavior
    Issue number4
    StatePublished - Oct 1992



    • Acquisition
    • Delayed alternation
    • Food-reinforcement
    • M520 strain
    • Memory
    • T-maze
    • Vasopressin
    • Vasopressin-deficient rats

    ASJC Scopus subject areas

    • Experimental and Cognitive Psychology
    • Behavioral Neuroscience

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