Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin

Giancarlo Colombo; Carl Hansen; Paula L. Hoffman; Kathleen A. Grant

doi:10.1016/0031-9384(92)90422-X

Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin

Giancarlo Colombo, Carl Hansen, Paula L. Hoffman, Kathleen A. Grant

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.

Original language	English (US)
Pages (from-to)	827-830
Number of pages	4
Journal	Physiology and Behavior
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(92)90422-X
State	Published - Oct 1992

Keywords

Acquisition
Delayed alternation
Food-reinforcement
M520 strain
Memory
T-maze
Vasopressin
Vasopressin-deficient rats

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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title = "Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin",

abstract = "Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.",

keywords = "Acquisition, Delayed alternation, Food-reinforcement, M520 strain, Memory, T-maze, Vasopressin, Vasopressin-deficient rats",

author = "Giancarlo Colombo and Carl Hansen and Hoffman, {Paula L.} and Grant, {Kathleen A.}",

year = "1992",

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language = "English (US)",

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T1 - Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin

AU - Colombo, Giancarlo

AU - Hansen, Carl

AU - Hoffman, Paula L.

AU - Grant, Kathleen A.

PY - 1992/10

Y1 - 1992/10

N2 - Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.

AB - Acquisition and retention of a delayed alternation task by rats genetically deficient in vasopressin (AVP) due to the homozygous occurrence of the Brattleboro diabetes insipidus (DI) gene (M520/DI) were compared to the response of rats that were heterozygous (M520/HZ) or normal (M520/N) with respect to the DI gene. No significant difference in the adaptation to the apparatus was observed between the groups. However, the rate at which the M520/DI rats acquired the alternation task was significantly slower than the acquisition rates of M520/HZ and M520/N rats. In addition, the maximum intertrial interval reached by the M520/DI rats was significantly shorter than the intertrial intervals reached by the M520/HZ and M520/N rats, indicating the ability to retain information was impaired in the M520/DI rats. These results are consistent with the hypothesis that AVP modulates the acquisition and retention of information for normal memory processes.

KW - Acquisition

KW - Delayed alternation

KW - Food-reinforcement

KW - M520 strain

KW - Memory

KW - T-maze

KW - Vasopressin

KW - Vasopressin-deficient rats

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