Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy

Smita A. Ghanekar, Sharon A. Stranford, June C. Ong, Joshua M. Walker, Vernon C. Maino, Jay A. Levy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.

Original languageEnglish (US)
Pages (from-to)1885-1887
Number of pages3
JournalAIDS
Volume15
Issue number14
DOIs
StatePublished - Sep 28 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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