Decreased FOXP3 levels in multiple sclerosis patients

Jianya Huan, Nicole Culbertson, Leslie Spencer, Richard Bartholomew, Gregory G. Burrows, Yuan K. Chou, Dennis Bourdette, Steven F. Ziegler, Halina Offner, Arthur Vandenbark

Research output: Contribution to journalArticle

272 Scopus citations

Abstract

Autoimmune diseases such as multiple sclerosis (MS) may result from the failure of tolerance mechanisms to prevent expansion of pathogenic T cells. Our study is the first to establish that MS patients have abnormalities in FOXP3 message and protein expression levels in peripheral CD4+CD25 + T cells (Tregs) that are quantitatively related to a reduction in functional suppression induced during suboptimal T-cell receptor (TCR) ligation. Of importance, this observation links a defect in functional peripheral immunoregulation to an established genetic marker that has been unequivocally shown to be involved in maintaining immune tolerance and preventing autoimmune diseases. Diminished FOXP3 levels thus indicate impaired immunoregulation by Tregs that may contribute to MS. Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalJournal of Neuroscience Research
Volume81
Issue number1
DOIs
Publication statusPublished - Jul 1 2005

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Keywords

  • FOXP3
  • Multiple sclerosis
  • Treg cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Huan, J., Culbertson, N., Spencer, L., Bartholomew, R., Burrows, G. G., Chou, Y. K., ... Vandenbark, A. (2005). Decreased FOXP3 levels in multiple sclerosis patients. Journal of Neuroscience Research, 81(1), 45-52. https://doi.org/10.1002/jnr.20522