Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers

N. D. Volkow, J. S. Fowler, G. J. Wang, Robert Hitzemann, J. Logan, D. J. Schlyer, S. L. Dewey, A. P. Wolf

Research output: Contribution to journalArticle

675 Citations (Scopus)

Abstract

Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach was used to examine dopamine D2 receptor availability and regional brain glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3-4 months after detoxification. Decreases in dopamine D2 receptor availability were associated with decreased metabolism in several regions of the frontal lobes, most markedly orbito-frontal cortex and cingulate gyri. Dopamine dysregulation of these brain areas which are involved in the channeling of drive and affect could lead to loss of control resulting in compulsive drug-taking behavior.

Original languageEnglish (US)
Pages (from-to)169-177
Number of pages9
JournalSynapse
Volume14
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Cocaine
Frontal Lobe
Dopamine
Brain
Cocaine-Related Disorders
Self Administration
Gyrus Cinguli
Positron-Emission Tomography
Glucose
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology

Cite this

Volkow, N. D., Fowler, J. S., Wang, G. J., Hitzemann, R., Logan, J., Schlyer, D. J., ... Wolf, A. P. (1993). Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse, 14(2), 169-177. https://doi.org/10.1002/syn.890140210

Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. / Volkow, N. D.; Fowler, J. S.; Wang, G. J.; Hitzemann, Robert; Logan, J.; Schlyer, D. J.; Dewey, S. L.; Wolf, A. P.

In: Synapse, Vol. 14, No. 2, 1993, p. 169-177.

Research output: Contribution to journalArticle

Volkow, ND, Fowler, JS, Wang, GJ, Hitzemann, R, Logan, J, Schlyer, DJ, Dewey, SL & Wolf, AP 1993, 'Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers', Synapse, vol. 14, no. 2, pp. 169-177. https://doi.org/10.1002/syn.890140210
Volkow, N. D. ; Fowler, J. S. ; Wang, G. J. ; Hitzemann, Robert ; Logan, J. ; Schlyer, D. J. ; Dewey, S. L. ; Wolf, A. P. / Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. In: Synapse. 1993 ; Vol. 14, No. 2. pp. 169-177.
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