Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy

Elizabeth J. Sutton, Ricky T. Tong, Amy M. Gillis, Tobias D. Henning, Vivian A. Weinberg, Sophie Boddington, Daphne A. Haas-Kogan, Katherine Matthay, Vinil Sha, Charles Gooding, Fergus Coakley, Heike Daldrup-Link

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Long-term CT follow-up studies are required in pediatric patients who have received intraoperative radiation therapy (IORT) and external beam radiation therapy (EBRT) to assess vascular toxicities and to determine the exact complication rate. Objective: To analyze with CT the effects of radiation therapy (RT) on the growth of the aorta in neuroblastoma patients. Materials and methods: Abdominal CT scans of 31 patients with intraabdominal neuroblastoma (stage II-IV), treated with RT (20 IORT±EBRT, 11 EBRT alone), were analyzed retrospectively. The diameter of the abdominal aorta was measured before and after RT. These data were compared to normal and predicted normal aortic diameters of children, according to the model of Fitzgerald, Donaldson and Poznanski (aortic diameter in centimeters=0.844+0.0599×age in years), and to the diameters of a control group of children who had not undergone RT. Statistical analyses for the primary aims were performed using the chi-squared test, t-test, Mann-Whitney test, nonparametric Wilcoxon matched-pairs test and analysis of variance for repeated measures. Clinical files and imaging studies were evaluated for signs of late vascular complications of neuroblastoma patients who had received RT. Results: The mean diameter before and after RT and the growth of the aorta were significantly lower than expected in patients with neuroblastoma (P

Original languageEnglish (US)
Pages (from-to)1194-1202
Number of pages9
JournalPediatric Radiology
Volume39
Issue number11
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Neuroblastoma
Radiotherapy
Growth
Blood Vessels
Aorta
Matched-Pair Analysis
Abdominal Aorta
Analysis of Variance
Pediatrics
Control Groups

Keywords

  • Children
  • Intraoperative irradiation
  • Middle aortic syndrome
  • Neuroblastoma
  • Therapy complications

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

Cite this

Sutton, E. J., Tong, R. T., Gillis, A. M., Henning, T. D., Weinberg, V. A., Boddington, S., ... Daldrup-Link, H. (2009). Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy. Pediatric Radiology, 39(11), 1194-1202. https://doi.org/10.1007/s00247-009-1351-1

Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy. / Sutton, Elizabeth J.; Tong, Ricky T.; Gillis, Amy M.; Henning, Tobias D.; Weinberg, Vivian A.; Boddington, Sophie; Haas-Kogan, Daphne A.; Matthay, Katherine; Sha, Vinil; Gooding, Charles; Coakley, Fergus; Daldrup-Link, Heike.

In: Pediatric Radiology, Vol. 39, No. 11, 11.2009, p. 1194-1202.

Research output: Contribution to journalArticle

Sutton, EJ, Tong, RT, Gillis, AM, Henning, TD, Weinberg, VA, Boddington, S, Haas-Kogan, DA, Matthay, K, Sha, V, Gooding, C, Coakley, F & Daldrup-Link, H 2009, 'Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy', Pediatric Radiology, vol. 39, no. 11, pp. 1194-1202. https://doi.org/10.1007/s00247-009-1351-1
Sutton, Elizabeth J. ; Tong, Ricky T. ; Gillis, Amy M. ; Henning, Tobias D. ; Weinberg, Vivian A. ; Boddington, Sophie ; Haas-Kogan, Daphne A. ; Matthay, Katherine ; Sha, Vinil ; Gooding, Charles ; Coakley, Fergus ; Daldrup-Link, Heike. / Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy. In: Pediatric Radiology. 2009 ; Vol. 39, No. 11. pp. 1194-1202.
@article{808cb2d34da444abb4e4316486f9eef0,
title = "Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy",
abstract = "Background: Long-term CT follow-up studies are required in pediatric patients who have received intraoperative radiation therapy (IORT) and external beam radiation therapy (EBRT) to assess vascular toxicities and to determine the exact complication rate. Objective: To analyze with CT the effects of radiation therapy (RT) on the growth of the aorta in neuroblastoma patients. Materials and methods: Abdominal CT scans of 31 patients with intraabdominal neuroblastoma (stage II-IV), treated with RT (20 IORT±EBRT, 11 EBRT alone), were analyzed retrospectively. The diameter of the abdominal aorta was measured before and after RT. These data were compared to normal and predicted normal aortic diameters of children, according to the model of Fitzgerald, Donaldson and Poznanski (aortic diameter in centimeters=0.844+0.0599×age in years), and to the diameters of a control group of children who had not undergone RT. Statistical analyses for the primary aims were performed using the chi-squared test, t-test, Mann-Whitney test, nonparametric Wilcoxon matched-pairs test and analysis of variance for repeated measures. Clinical files and imaging studies were evaluated for signs of late vascular complications of neuroblastoma patients who had received RT. Results: The mean diameter before and after RT and the growth of the aorta were significantly lower than expected in patients with neuroblastoma (P",
keywords = "Children, Intraoperative irradiation, Middle aortic syndrome, Neuroblastoma, Therapy complications",
author = "Sutton, {Elizabeth J.} and Tong, {Ricky T.} and Gillis, {Amy M.} and Henning, {Tobias D.} and Weinberg, {Vivian A.} and Sophie Boddington and Haas-Kogan, {Daphne A.} and Katherine Matthay and Vinil Sha and Charles Gooding and Fergus Coakley and Heike Daldrup-Link",
year = "2009",
month = "11",
doi = "10.1007/s00247-009-1351-1",
language = "English (US)",
volume = "39",
pages = "1194--1202",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy

AU - Sutton, Elizabeth J.

AU - Tong, Ricky T.

AU - Gillis, Amy M.

AU - Henning, Tobias D.

AU - Weinberg, Vivian A.

AU - Boddington, Sophie

AU - Haas-Kogan, Daphne A.

AU - Matthay, Katherine

AU - Sha, Vinil

AU - Gooding, Charles

AU - Coakley, Fergus

AU - Daldrup-Link, Heike

PY - 2009/11

Y1 - 2009/11

N2 - Background: Long-term CT follow-up studies are required in pediatric patients who have received intraoperative radiation therapy (IORT) and external beam radiation therapy (EBRT) to assess vascular toxicities and to determine the exact complication rate. Objective: To analyze with CT the effects of radiation therapy (RT) on the growth of the aorta in neuroblastoma patients. Materials and methods: Abdominal CT scans of 31 patients with intraabdominal neuroblastoma (stage II-IV), treated with RT (20 IORT±EBRT, 11 EBRT alone), were analyzed retrospectively. The diameter of the abdominal aorta was measured before and after RT. These data were compared to normal and predicted normal aortic diameters of children, according to the model of Fitzgerald, Donaldson and Poznanski (aortic diameter in centimeters=0.844+0.0599×age in years), and to the diameters of a control group of children who had not undergone RT. Statistical analyses for the primary aims were performed using the chi-squared test, t-test, Mann-Whitney test, nonparametric Wilcoxon matched-pairs test and analysis of variance for repeated measures. Clinical files and imaging studies were evaluated for signs of late vascular complications of neuroblastoma patients who had received RT. Results: The mean diameter before and after RT and the growth of the aorta were significantly lower than expected in patients with neuroblastoma (P

AB - Background: Long-term CT follow-up studies are required in pediatric patients who have received intraoperative radiation therapy (IORT) and external beam radiation therapy (EBRT) to assess vascular toxicities and to determine the exact complication rate. Objective: To analyze with CT the effects of radiation therapy (RT) on the growth of the aorta in neuroblastoma patients. Materials and methods: Abdominal CT scans of 31 patients with intraabdominal neuroblastoma (stage II-IV), treated with RT (20 IORT±EBRT, 11 EBRT alone), were analyzed retrospectively. The diameter of the abdominal aorta was measured before and after RT. These data were compared to normal and predicted normal aortic diameters of children, according to the model of Fitzgerald, Donaldson and Poznanski (aortic diameter in centimeters=0.844+0.0599×age in years), and to the diameters of a control group of children who had not undergone RT. Statistical analyses for the primary aims were performed using the chi-squared test, t-test, Mann-Whitney test, nonparametric Wilcoxon matched-pairs test and analysis of variance for repeated measures. Clinical files and imaging studies were evaluated for signs of late vascular complications of neuroblastoma patients who had received RT. Results: The mean diameter before and after RT and the growth of the aorta were significantly lower than expected in patients with neuroblastoma (P

KW - Children

KW - Intraoperative irradiation

KW - Middle aortic syndrome

KW - Neuroblastoma

KW - Therapy complications

UR - http://www.scopus.com/inward/record.url?scp=72849145452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72849145452&partnerID=8YFLogxK

U2 - 10.1007/s00247-009-1351-1

DO - 10.1007/s00247-009-1351-1

M3 - Article

C2 - 19763559

AN - SCOPUS:72849145452

VL - 39

SP - 1194

EP - 1202

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

IS - 11

ER -