TY - JOUR
T1 - Decoding Parkinson's Disease Pathogenesis
T2 - The Role of Deregulated mRNA Translation
AU - Martin, Ian
N1 - Publisher Copyright:
© 2016 - IOS Press and the authors. All rights reserved.
PY - 2016/3/30
Y1 - 2016/3/30
N2 - Mutations in a number of genes cause rare familial forms of Parkinson's disease and provide profound insight into potential mechanisms governing disease pathogenesis. Recently, a role for translation and metabolism of mRNA has emerged in the development of various neurodegenerative disorders including Parkinson's disease (PD). In PD, preliminary evidence supports a role for aberrant translation in the disease process stemming from mutations in several genes. Translation control is central to maintaining organism homeostasis under variable environmental conditions and deregulation of this may predispose to certain stressors. Hypothetically, deregulated translation may be detrimental to neuronal viability in PD through the misexpression of a subset of transcripts or through the impact of excessive bulk translation on energy consumption and burden on protein homeostatic mechanisms. While compelling preliminary evidence exists to support a role for translation in PD, much more work is required to identify specific mechanisms linking altered translation to the disease process.
AB - Mutations in a number of genes cause rare familial forms of Parkinson's disease and provide profound insight into potential mechanisms governing disease pathogenesis. Recently, a role for translation and metabolism of mRNA has emerged in the development of various neurodegenerative disorders including Parkinson's disease (PD). In PD, preliminary evidence supports a role for aberrant translation in the disease process stemming from mutations in several genes. Translation control is central to maintaining organism homeostasis under variable environmental conditions and deregulation of this may predispose to certain stressors. Hypothetically, deregulated translation may be detrimental to neuronal viability in PD through the misexpression of a subset of transcripts or through the impact of excessive bulk translation on energy consumption and burden on protein homeostatic mechanisms. While compelling preliminary evidence exists to support a role for translation in PD, much more work is required to identify specific mechanisms linking altered translation to the disease process.
UR - http://www.scopus.com/inward/record.url?scp=84963779656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963779656&partnerID=8YFLogxK
U2 - 10.3233/JPD-150738
DO - 10.3233/JPD-150738
M3 - Review article
C2 - 26889638
AN - SCOPUS:84963779656
SN - 1877-7171
VL - 6
SP - 17
EP - 27
JO - Journal of Parkinson's Disease
JF - Journal of Parkinson's Disease
IS - 1
ER -