Decoding Parkinson's Disease Pathogenesis

The Role of Deregulated mRNA Translation

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Mutations in a number of genes cause rare familial forms of Parkinson's disease and provide profound insight into potential mechanisms governing disease pathogenesis. Recently, a role for translation and metabolism of mRNA has emerged in the development of various neurodegenerative disorders including Parkinson's disease (PD). In PD, preliminary evidence supports a role for aberrant translation in the disease process stemming from mutations in several genes. Translation control is central to maintaining organism homeostasis under variable environmental conditions and deregulation of this may predispose to certain stressors. Hypothetically, deregulated translation may be detrimental to neuronal viability in PD through the misexpression of a subset of transcripts or through the impact of excessive bulk translation on energy consumption and burden on protein homeostatic mechanisms. While compelling preliminary evidence exists to support a role for translation in PD, much more work is required to identify specific mechanisms linking altered translation to the disease process.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalJournal of Parkinson's Disease
Volume6
Issue number1
DOIs
StatePublished - Mar 30 2016

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Protein Biosynthesis
Parkinson Disease
Mutation
Neurodegenerative Diseases
Genes
Homeostasis
Proteins

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Decoding Parkinson's Disease Pathogenesis : The Role of Deregulated mRNA Translation. / Martin, Ian.

In: Journal of Parkinson's Disease, Vol. 6, No. 1, 30.03.2016, p. 17-27.

Research output: Contribution to journalReview article

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