Decision support for clinical trial eligibility determination in breast cancer.

L. Ohno-Machado, Samuel Wang, P. Mar, A. A. Boxwala

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We have developed a system for clinical trial eligibility determination where patients or primary care providers can enter clinical information about a patient and obtain a ranked list of clinical trials for which the patient is likely to be eligible. We used clinical trial eligibility information from the National Cancer Institute's Physician Data Query (PDQ) database. We translated each free-text eligibility criterion into a machine executable statement using a derivation of the Arden Syntax. Clinical trial protocols were then structured as collections of these eligibility criteria using XML. The application compares the entered patient information against each of the eligibility criteria and returns a numerical score. Results are displayed in order of likelihood of match. We have tested our system using all phase II and III clinical trials for treatment of metastatic breast cancer found in the PDQ database. Preliminary results are encouraging.

Original languageEnglish (US)
Pages (from-to)340-344
Number of pages5
JournalProceedings / AMIA ... Annual Symposium. AMIA Symposium
StatePublished - 1999
Externally publishedYes

Fingerprint

Eligibility Determination
Clinical Trials
Breast Neoplasms
Clinical Protocols
Databases
Physicians
Phase III Clinical Trials
Phase II Clinical Trials
National Cancer Institute (U.S.)
Primary Health Care
Patient Care

Cite this

Decision support for clinical trial eligibility determination in breast cancer. / Ohno-Machado, L.; Wang, Samuel; Mar, P.; Boxwala, A. A.

In: Proceedings / AMIA ... Annual Symposium. AMIA Symposium, 1999, p. 340-344.

Research output: Contribution to journalArticle

@article{7644112ec25d472ea497d42821297693,
title = "Decision support for clinical trial eligibility determination in breast cancer.",
abstract = "We have developed a system for clinical trial eligibility determination where patients or primary care providers can enter clinical information about a patient and obtain a ranked list of clinical trials for which the patient is likely to be eligible. We used clinical trial eligibility information from the National Cancer Institute's Physician Data Query (PDQ) database. We translated each free-text eligibility criterion into a machine executable statement using a derivation of the Arden Syntax. Clinical trial protocols were then structured as collections of these eligibility criteria using XML. The application compares the entered patient information against each of the eligibility criteria and returns a numerical score. Results are displayed in order of likelihood of match. We have tested our system using all phase II and III clinical trials for treatment of metastatic breast cancer found in the PDQ database. Preliminary results are encouraging.",
author = "L. Ohno-Machado and Samuel Wang and P. Mar and Boxwala, {A. A.}",
year = "1999",
language = "English (US)",
pages = "340--344",
journal = "Proceedings / AMIA . Annual Symposium. AMIA Symposium",
issn = "1531-605X",
publisher = "Hanley & Belfus",

}

TY - JOUR

T1 - Decision support for clinical trial eligibility determination in breast cancer.

AU - Ohno-Machado, L.

AU - Wang, Samuel

AU - Mar, P.

AU - Boxwala, A. A.

PY - 1999

Y1 - 1999

N2 - We have developed a system for clinical trial eligibility determination where patients or primary care providers can enter clinical information about a patient and obtain a ranked list of clinical trials for which the patient is likely to be eligible. We used clinical trial eligibility information from the National Cancer Institute's Physician Data Query (PDQ) database. We translated each free-text eligibility criterion into a machine executable statement using a derivation of the Arden Syntax. Clinical trial protocols were then structured as collections of these eligibility criteria using XML. The application compares the entered patient information against each of the eligibility criteria and returns a numerical score. Results are displayed in order of likelihood of match. We have tested our system using all phase II and III clinical trials for treatment of metastatic breast cancer found in the PDQ database. Preliminary results are encouraging.

AB - We have developed a system for clinical trial eligibility determination where patients or primary care providers can enter clinical information about a patient and obtain a ranked list of clinical trials for which the patient is likely to be eligible. We used clinical trial eligibility information from the National Cancer Institute's Physician Data Query (PDQ) database. We translated each free-text eligibility criterion into a machine executable statement using a derivation of the Arden Syntax. Clinical trial protocols were then structured as collections of these eligibility criteria using XML. The application compares the entered patient information against each of the eligibility criteria and returns a numerical score. Results are displayed in order of likelihood of match. We have tested our system using all phase II and III clinical trials for treatment of metastatic breast cancer found in the PDQ database. Preliminary results are encouraging.

UR - http://www.scopus.com/inward/record.url?scp=0033258075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033258075&partnerID=8YFLogxK

M3 - Article

C2 - 10566377

AN - SCOPUS:0033258075

SP - 340

EP - 344

JO - Proceedings / AMIA . Annual Symposium. AMIA Symposium

JF - Proceedings / AMIA . Annual Symposium. AMIA Symposium

SN - 1531-605X

ER -