Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis

Priscilla McAuliffe, Funda Meric-Bernstam, Gordon Mills, Ana Gonzalez-Angulo

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression, and outcomes, including growth and proliferation, metabolism, motility, migration, invasion, angiogenesis, survival, and autophagy. Tight regulation of this pathway is paramount to ensure that multiple cellular inputs are integrated for appropriate cellular outcomes. Frequent deregulation and aberrations of this pathway have been implicated in breast cancer development and progression. This review focuses on the biology of this pathway and its role in breast cancer pathogenesis. The role of therapies directed at targeting mTOR in the PI3K/Akt/mTOR pathway, which are currently being evaluated in clinical trials, will also be reviewed.

Original languageEnglish (US)
Pages (from-to)S59-S65
JournalClinical Breast Cancer
Volume10
Issue numberSUPPL. 3
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Keywords

  • HER2
  • Mammalian target of rapamycin
  • PTEN
  • Phosphatidylinositol 3-kinase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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