Deciphering the MSG controversy

Jennifer S. Xiong, Debbie Branigan, Minghua Li

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Monosodium glutamate (MSG), a common flavor enhancer in various canned food and stereotypically associated with food in Chinese restaurants, has been claimed and tested to have side effects including headache and dizziness. However, the mechanism behind MSG-induced headache was not clear. Using dissociated mouse neuronal culture and cell injury assays, we determined whether incubation of neurons with clinically relevant concentrations of MSG induces cell swelling or death, and whether any measure can be taken to prevent or reduce MSG effects. We demonstrated that (1) Treatment with MSG induces a dose-dependent swelling and death of mature neurons (12-14 days in culture) with little effect on young immature neurons (

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalInternational Journal of Clinical and Experimental Medicine
Volume2
Issue number4
StatePublished - 2009

Fingerprint

Sodium Glutamate
Neurons
Headache
Swelling
Preserved Food
Restaurants
Flavors
Dizziness
Assays
Cell Culture Techniques
Food
Wounds and Injuries

Keywords

  • Headache
  • Injury
  • Monosodium glutamate
  • Neuron
  • Tolerance

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Deciphering the MSG controversy. / Xiong, Jennifer S.; Branigan, Debbie; Li, Minghua.

In: International Journal of Clinical and Experimental Medicine, Vol. 2, No. 4, 2009, p. 329-336.

Research output: Contribution to journalArticle

Xiong, Jennifer S. ; Branigan, Debbie ; Li, Minghua. / Deciphering the MSG controversy. In: International Journal of Clinical and Experimental Medicine. 2009 ; Vol. 2, No. 4. pp. 329-336.
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