Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis

Results after 12 months

M. Aimetti, F. Romano, I. Torta, D. Cirillo, Patrizia Caposio, R. Romagnoli

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Backgrounds, aims: The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions. Material and Methods: The study was conducted in a split-mouth design. Nineteen patients with at least four bilateral pockets 4-5 mm and bleeding on probing (BOP) were treated with scaling and root planing (SRP) plus TE fibres (test sites) or with SRP alone (control sites). Clinical and radiological measurements were taken at baseline, 6 months and 12 months post-operatively. Subgingival plaque samples were collected at baseline, at fibres removal, 6 and 12 months following treatment and analysed by polymerase chain reaction. Results: Both treatments yielded a statistically significant (p <0.05) reduction of probing depth (2.05 and 1.21 mm), gain of clinical attachment level (1.71 and 0.53 mm) and reduction of BOP scores (23.68% and 57.89%) for TE and SRP groups, respectively, when comparing 12-month data with baseline. The differences between two groups were significant. The prevalence of Treponema denticola and Bacteroides forsythus decreased after therapy in both groups but only in the test sites Actinobacillus actinomycetemcomitans and Prevotella intermedia were not yield detected. The pathogens could be eliminated from five periodontal pockets by SRP alone, while 21 TE sites were not recolonized at 12 months. Conclusions: SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalJournal of Clinical Periodontology
Volume31
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Root Planing
Periodontitis
Debridement
Tetracycline
Treponema denticola
Prevotella intermedia
Hemorrhage
Periodontal Pocket
Aggregatibacter actinomycetemcomitans
Therapeutics
Mouth
Polymerase Chain Reaction

Keywords

  • Actinobacillus actinomycetemcomitans
  • Bacteroides forsythus
  • Periodontal disease/microbiology
  • Periodontal disease/therapy
  • Porphyromonas gingivalis
  • Prevotella intermedia
  • Scaling and root planing
  • Tetracycline fibre
  • Treponema denticola

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis : Results after 12 months. / Aimetti, M.; Romano, F.; Torta, I.; Cirillo, D.; Caposio, Patrizia; Romagnoli, R.

In: Journal of Clinical Periodontology, Vol. 31, No. 3, 03.2004, p. 166-172.

Research output: Contribution to journalArticle

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abstract = "Backgrounds, aims: The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions. Material and Methods: The study was conducted in a split-mouth design. Nineteen patients with at least four bilateral pockets 4-5 mm and bleeding on probing (BOP) were treated with scaling and root planing (SRP) plus TE fibres (test sites) or with SRP alone (control sites). Clinical and radiological measurements were taken at baseline, 6 months and 12 months post-operatively. Subgingival plaque samples were collected at baseline, at fibres removal, 6 and 12 months following treatment and analysed by polymerase chain reaction. Results: Both treatments yielded a statistically significant (p <0.05) reduction of probing depth (2.05 and 1.21 mm), gain of clinical attachment level (1.71 and 0.53 mm) and reduction of BOP scores (23.68{\%} and 57.89{\%}) for TE and SRP groups, respectively, when comparing 12-month data with baseline. The differences between two groups were significant. The prevalence of Treponema denticola and Bacteroides forsythus decreased after therapy in both groups but only in the test sites Actinobacillus actinomycetemcomitans and Prevotella intermedia were not yield detected. The pathogens could be eliminated from five periodontal pockets by SRP alone, while 21 TE sites were not recolonized at 12 months. Conclusions: SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.",
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AB - Backgrounds, aims: The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions. Material and Methods: The study was conducted in a split-mouth design. Nineteen patients with at least four bilateral pockets 4-5 mm and bleeding on probing (BOP) were treated with scaling and root planing (SRP) plus TE fibres (test sites) or with SRP alone (control sites). Clinical and radiological measurements were taken at baseline, 6 months and 12 months post-operatively. Subgingival plaque samples were collected at baseline, at fibres removal, 6 and 12 months following treatment and analysed by polymerase chain reaction. Results: Both treatments yielded a statistically significant (p <0.05) reduction of probing depth (2.05 and 1.21 mm), gain of clinical attachment level (1.71 and 0.53 mm) and reduction of BOP scores (23.68% and 57.89%) for TE and SRP groups, respectively, when comparing 12-month data with baseline. The differences between two groups were significant. The prevalence of Treponema denticola and Bacteroides forsythus decreased after therapy in both groups but only in the test sites Actinobacillus actinomycetemcomitans and Prevotella intermedia were not yield detected. The pathogens could be eliminated from five periodontal pockets by SRP alone, while 21 TE sites were not recolonized at 12 months. Conclusions: SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.

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