Death by committee

Organellar trafficking and communication in apoptosis

Joseph Aslan, Gary Thomas

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Apoptosis proceeds through a set of evolutionarily conserved processes that co-ordinate the elimination of damaged or unneeded cells. This program of cell death is carried out by organelle-directed regulators, including the Bcl-2 proteins, and ultimately executed by proteases of the caspase family. Although the biochemical mechanisms of apoptosis are increasingly understood, the underlying cell biology orchestrating programmed cell death remains enigmatic. In this review, we summarize the current understanding of Bcl-2 protein regulation and caspase activation while examining cell biological mechanisms and consequences of apoptotic induction. Organellar contributions to apoptotic induction include death receptor endocytosis, mitochondrial and lysosomal permeabilization, endoplasmic reticulum calcium release and fragmentation of the Golgi apparatus. These early apoptotic events are accompanied by stabilization of the microtubule cytoskeleton and translocation of organelles to the microtubule organizing center. Together, these phenomena establish a model of apoptotic induction whereby a cytoskeletal-dependent coalescence and 'scrambling' of organelles in the paranuclear region co-ordinates apoptotic communication, caspase activation and cell death.

Original languageEnglish (US)
Pages (from-to)1390-1404
Number of pages15
JournalTraffic
Volume10
Issue number10
DOIs
StatePublished - Oct 2009

Fingerprint

Cell death
Caspases
Organelles
Cell Death
Apoptosis
Communication
Chemical activation
Microtubule-Organizing Center
Cytology
Death Domain Receptors
Golgi Apparatus
Endocytosis
Cytoskeleton
Coalescence
Microtubules
Endoplasmic Reticulum
Cell Biology
Proteins
Peptide Hydrolases
Stabilization

Keywords

  • 14-3-3
  • Bad
  • Bax
  • Bid
  • Cathepsin
  • Ceramide
  • Cytochrome c
  • Drp1
  • Dynein
  • GD3
  • Mitochondria
  • PACS-2
  • SUMO

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Structural Biology
  • Molecular Biology
  • Genetics

Cite this

Death by committee : Organellar trafficking and communication in apoptosis. / Aslan, Joseph; Thomas, Gary.

In: Traffic, Vol. 10, No. 10, 10.2009, p. 1390-1404.

Research output: Contribution to journalArticle

Aslan, Joseph ; Thomas, Gary. / Death by committee : Organellar trafficking and communication in apoptosis. In: Traffic. 2009 ; Vol. 10, No. 10. pp. 1390-1404.
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