De novo truncating mutation in kinesin 17 associated with schizophrenia

Julien Tarabeux, Nathalie Champagne, Edna Brustein, Fadi F. Hamdan, Julie Gauthier, Mathieu Lapointe, Claudia Maios, Amlie Piton, Dan Spiegelman, Édouard Henrion, Bruno Millet, Judith L. Rapoport, Lynn E. Delisi, Ridha Joober, Ferid Fathalli, Éric Fombonne, Laurent Mottron, Nadine Forget-Dubois, Michel Boivin, Jacques L. MichaudRonald G. Lafrenire, Pierre Drapeau, Marie Odile Krebs, Guy A. Rouleau

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Schizophrenia (SCZ) is one of the most disabling psychiatric disorders. It is thought to be due to a complex interplay between polygenic and various environmental risk factors, although recent reports on genomic copy number variations suggest that a fraction of the cases could result from variably penetrant de novo variants. The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in glutamatergic synapse is a candidate gene for SCZ. Methods: As part of our Synapse to Disease project, we resequenced KIF17 in a cohort of individuals with sporadic SCZ (188 subjects). Additional populations included autism spectrum disorder (142 subjects), nonsyndromic mental retardation (95 subjects), and control subjects (568 subjects). Functional validation of the human mutation was done in developing zebrafish. Results: Here we report the identification of a de novo nonsense truncating mutation in one patient with SCZ, in kinesin 17, a synaptic motor protein. No de novo or truncating KIF17 mutations were found in the additional samples. We further validated the pathogenic nature of this mutation by knocking down its expression in zebrafish embryos, which resulted in a developmental defect. Conclusions: Together our findings suggest that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder.

Original languageEnglish (US)
Pages (from-to)649-656
Number of pages8
JournalBiological Psychiatry
Volume68
Issue number7
DOIs
StatePublished - Oct 1 2010

Keywords

  • De novo
  • KIF17
  • NMDA
  • kinesin
  • schizophrenia
  • synapse

ASJC Scopus subject areas

  • Biological Psychiatry

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  • Cite this

    Tarabeux, J., Champagne, N., Brustein, E., Hamdan, F. F., Gauthier, J., Lapointe, M., Maios, C., Piton, A., Spiegelman, D., Henrion, É., Millet, B., Rapoport, J. L., Delisi, L. E., Joober, R., Fathalli, F., Fombonne, É., Mottron, L., Forget-Dubois, N., Boivin, M., ... Rouleau, G. A. (2010). De novo truncating mutation in kinesin 17 associated with schizophrenia. Biological Psychiatry, 68(7), 649-656. https://doi.org/10.1016/j.biopsych.2010.04.018