TY - GEN
T1 - De Novo proteomics of neuronal ischemic tolerance
AU - Zhou, An
AU - David, Larry
AU - Simon, Roger
PY - 2010
Y1 - 2010
N2 - In a recent proteomic characterization of ischemic-tolerant rodent brains, we discovered an enriched presence of repressive transcriptional regulator proteins with essential roles as epigenetic regulators inducing tolerance to ischemia in brain (1). We further showed their robust, dynamic and differential changes under different ischemic conditions in brain. In the present work, we aimed to characterize the de novo proteome, the proteome that presents early during the induction of ischemic tolerance. These would be the proteomic changes of newly synthesized proteins at the initiation of the tolerant phenotype. Identification of effectors of this phase of tolerance induction bears the best promise of identifying therapeutic targets for treating acute stroke when patients present to hospital. We compare these de novo results to those in fully developed tolerant brains.
AB - In a recent proteomic characterization of ischemic-tolerant rodent brains, we discovered an enriched presence of repressive transcriptional regulator proteins with essential roles as epigenetic regulators inducing tolerance to ischemia in brain (1). We further showed their robust, dynamic and differential changes under different ischemic conditions in brain. In the present work, we aimed to characterize the de novo proteome, the proteome that presents early during the induction of ischemic tolerance. These would be the proteomic changes of newly synthesized proteins at the initiation of the tolerant phenotype. Identification of effectors of this phase of tolerance induction bears the best promise of identifying therapeutic targets for treating acute stroke when patients present to hospital. We compare these de novo results to those in fully developed tolerant brains.
KW - Gene ontology
KW - Proteomics
KW - Transcription network
UR - http://www.scopus.com/inward/record.url?scp=77958061592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958061592&partnerID=8YFLogxK
U2 - 10.1145/1854776.1854880
DO - 10.1145/1854776.1854880
M3 - Conference contribution
AN - SCOPUS:77958061592
SN - 9781450304382
T3 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
SP - 552
EP - 555
BT - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
T2 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Y2 - 2 August 2010 through 4 August 2010
ER -