De Novo proteomics of neuronal ischemic tolerance

An Zhou, Larry David, Roger Simon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In a recent proteomic characterization of ischemic-tolerant rodent brains, we discovered an enriched presence of repressive transcriptional regulator proteins with essential roles as epigenetic regulators inducing tolerance to ischemia in brain (1). We further showed their robust, dynamic and differential changes under different ischemic conditions in brain. In the present work, we aimed to characterize the de novo proteome, the proteome that presents early during the induction of ischemic tolerance. These would be the proteomic changes of newly synthesized proteins at the initiation of the tolerant phenotype. Identification of effectors of this phase of tolerance induction bears the best promise of identifying therapeutic targets for treating acute stroke when patients present to hospital. We compare these de novo results to those in fully developed tolerant brains.

Original languageEnglish (US)
Title of host publication2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Pages552-555
Number of pages4
DOIs
StatePublished - Oct 25 2010
Event2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010 - Niagara Falls, NY, United States
Duration: Aug 2 2010Aug 4 2010

Publication series

Name2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010

Other

Other2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
CountryUnited States
CityNiagara Falls, NY
Period8/2/108/4/10

Keywords

  • Gene ontology
  • Proteomics
  • Transcription network

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Information Management

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