Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions

F. A J L Scheer, J. L. Chan, J. Fargnoli, J. Chamberland, K. Arampatzi, Steven Shea, G. L. Blackburn, C. S. Mantzoros

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aims/hypothesis: Adiponectin and lipocalin-2 are adipocyte-derived plasma proteins that have been proposed to have opposite effects on insulin sensitivity. Given the epidemiological, physiological and molecular links between sleep, the circadian timing system and glucose metabolism, the aim of this study was to assess effects of the sleep/wake cycle and the fasting/feeding cycle on high-molecular-weight adiponectin (HMW-adiponectin; the biologically active form) and lipocalin-2. We also aimed to compare the 24 h rhythms in the levels of these proteins with those of cortisol, leptin, leptin-binding protein and total adiponectin. Methods: Lean men underwent a 3 day in-laboratory study, either in the fed state (n=8, age: 20.9±2.1 years, BMI: 22.8±2.3 kg/m2) or fasting state (3 day fast, n=4, age: 25.3±3.9 years, BMI: 23.3±2.2 kg/m2). The sleep episode was scheduled in darkness from 23:00 to 07:00 hours. Blood was sampled every 15 min for 24 h on the third day of each study. Results: While fed, HMW-adiponectin and lipocalin-2 had large daily rhythms with troughs at night (HMW-adiponectin: ~04:00 hours, peak-to-trough amplitude 36%, p

Original languageEnglish (US)
Pages (from-to)2401-2405
Number of pages5
JournalDiabetologia
Volume53
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Adiponectin
Molecular Weight
Sleep
Fasting
Leptin Receptors
Circadian Clocks
Darkness
Leptin
Adipocytes
Insulin Resistance
Hydrocortisone
Lipocalin-2
Blood Proteins
Glucose
Proteins

Keywords

  • Cortisol
  • Fasting
  • High-molecular-weight adiponectin
  • Leptin
  • Leptin-binding protein
  • Lipocalin-2
  • Nutrition
  • Sleep/wake cycle
  • Soluble leptin receptor
  • Total adiponectin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Scheer, F. A. J. L., Chan, J. L., Fargnoli, J., Chamberland, J., Arampatzi, K., Shea, S., ... Mantzoros, C. S. (2010). Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia, 53(11), 2401-2405. https://doi.org/10.1007/s00125-010-1869-7

Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. / Scheer, F. A J L; Chan, J. L.; Fargnoli, J.; Chamberland, J.; Arampatzi, K.; Shea, Steven; Blackburn, G. L.; Mantzoros, C. S.

In: Diabetologia, Vol. 53, No. 11, 11.2010, p. 2401-2405.

Research output: Contribution to journalArticle

Scheer, FAJL, Chan, JL, Fargnoli, J, Chamberland, J, Arampatzi, K, Shea, S, Blackburn, GL & Mantzoros, CS 2010, 'Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions', Diabetologia, vol. 53, no. 11, pp. 2401-2405. https://doi.org/10.1007/s00125-010-1869-7
Scheer, F. A J L ; Chan, J. L. ; Fargnoli, J. ; Chamberland, J. ; Arampatzi, K. ; Shea, Steven ; Blackburn, G. L. ; Mantzoros, C. S. / Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. In: Diabetologia. 2010 ; Vol. 53, No. 11. pp. 2401-2405.
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