@article{b2f6dd495ba34e3a87859557ed81a023,
title = "Data descriptor: Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy",
abstract = "Cross sectional imaging is essential for the patient-specific planning and delivery of radiotherapy, a primary determinant of head and neck cancer outcomes. Due to challenges ensuring data quality and patient de-identification, publicly available datasets including diagnostic and radiation treatment planning imaging are scarce. In this data descriptor, we detail the collection and processing of computed tomography based imaging in 215 patients with head and neck squamous cell carcinoma that were treated with radiotherapy. Using cross sectional imaging, we calculated total body skeletal muscle and adipose content before and after treatment. We detail techniques for validating the high quality of these data and describe the processes of data de-identification and transfer. All imaging data are subject-and date-matched to clinical data from each patient, including demographics, risk factors, grade, stage, recurrence, and survival. These data are a valuable resource for studying the association between patient-specific anatomic and metabolic features, treatment planning, and oncologic outcomes, and the first that allows for the integration of body composition as a risk factor or study outcome.",
author = "Grossberg, {Aaron J.} and Mohamed, {Abdallah S.R.} and {El Halawani}, Hesham and Bennett, {William C.} and Smith, {Kirk E.} and Nolan, {Tracy S.} and Bowman Williams and Sasikarn Chamchod and Jolien Heukelom and Kantor, {Michael E.} and Theodora Browne and Hutcheson, {Katherine A.} and Gunn, {G. Brandon} and Garden, {Adam S.} and Morrison, {William H.} and Frank, {Steven J.} and Rosenthal, {David I.} and Freymann, {John B.} and Fuller, {Clifton D.}",
note = "Funding Information: This research was supported by the Andrew Sabin Family Foundation; Dr. Fuller is a Sabin Family Foundation Fellow. Drs. Mohamed and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (NIDCR) (R01DE025248) and the National Institutes of Health (NIH)/National Cancer Institute (NCI) (1R01CA214825-01). Dr. Fuller received/(s) grant and/or salary support from the NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Career Development Award (P50CA097007-10); the NCI Paul Calabresi Clinical Oncology Program Award (K12 CA088084-06); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; the MD Anderson Institutional Research Grant (IRG) Program; and the NIH/NCI Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center (P30 CA016672). Dr. Elhalawani was directly funded in part by a philanthropic gift from the Family of Paul W. Beach given to Dr. Gunn for patient-outcome database construction.",
year = "2018",
doi = "10.1038/sdata.2018.173",
language = "English (US)",
volume = "5",
journal = "Scientific data",
issn = "2052-4463",
publisher = "Nature Publishing Group",
}