DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma

Jun Ma, Peg Strub, Phillip W. Lavori, A (Sonia) Buist, Carlos A. Camargo, Kari C. Nadeau, Sandra R. Wilson, Lan Xiao

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of Dietary Approaches to Stop Hypertension (DASH) as adjunct therapy to standard care for adults with uncontrolled asthma. The DASH diet encompasses foods (e.g., fresh fruit, vegetables, and nuts) and antioxidant nutrients (e.g., vitamins A, C, E, and zinc) with potential benefits for persons with asthma, but it is unknown whether the whole diet is beneficial. Participants (n = 90) will be randomized to receive usual care alone or combined with a DASH intervention consisting of 8 group and 3 individual sessions during the first 3. months, followed by at least monthly phone consultations for another 3. months. Follow-up assessments will occur at 3 and 6. months. The primary outcome measure is the 7-item Juniper Asthma Control Questionnaire, a validated composite measure of daytime and nocturnal symptoms, activity limitations, rescue medication use, and percentage predicted forced expiratory volume in 1. second. We will explore changes in inflammatory markers important to asthma pathophysiology (e.g., fractional exhaled nitric oxide) and their potential to mediate the intervention effect on disease control. We will also conduct pre-specified subgroup analyses by genotype (e.g., polymorphisms on the glutathione S transferase gene) and phenotype (e.g., atopy, obesity). By evaluating a dietary pattern approach to improving asthma control, this study could advance the evidence base for refining clinical guidelines and public health recommendations regarding the role of dietary modifications in asthma management.

Original languageEnglish (US)
Pages (from-to)55-67
Number of pages13
JournalContemporary Clinical Trials
Volume35
Issue number2
DOIs
Publication statusPublished - Jul 2013

    Fingerprint

Keywords

  • Asthma
  • Asthma Control Questionnaire
  • DASH
  • Dietary pattern
  • Lung function

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

Cite this