Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability

Daniel S. Reich, Seth A. Smith, Eliza M. Gordon-Lipkin, Arzu Ozturk, Brian S. Caffo, Laura J. Balcer, Peter A. Calabresi

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Objective: To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction. Design: Case-control study. Setting: Referral center. Participants: Ninety referred patients with MS and 29 healthy volunteers. Main Outcome Measures: Magnetic resonance imaging indices along the OR were reconstructed with diffusion tensor tractography. Retinal nerve fiber layer thickness and visual acuity at high and low contrast were measured in a subset of the MS group (n=36). Results: All tested magnetic resonance imaging indices (fractional anisotropy [FA]; mean, parallel, and perpendicular [λ⊥] diffusivity; T2 relaxation time; and magnetization transfer ratio) were significantly abnormal in patients with MS. Mean retinal nerve fiber layer thickness was significantly correlated with FA (r=0.55; P80 μm), letter acuity scores at 2.5% contrast were correlated with OR-specific FA (r=0.55; P=.004), λ⊥ (r=-0.40; P=.04), and magnetization transfer ratio (r=0.54; P=.01), as well as the fraction of OR volume made up of lesions (r=-0.69; P

Original languageEnglish (US)
Pages (from-to)998-1006
Number of pages9
JournalArchives of Neurology
Volume66
Issue number8
DOIs
StatePublished - Aug 2009
Externally publishedYes

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Multiple Sclerosis
Anisotropy
Radiation
Wounds and Injuries
Nerve Fibers
Magnetic Resonance Imaging
Optic Nerve Injuries
Diffusion Tensor Imaging
Visual Acuity
Case-Control Studies
Healthy Volunteers
Referral and Consultation
Outcome Assessment (Health Care)
Damage
Optics
Nerve
Layer
Fiber
Thickness

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Reich, D. S., Smith, S. A., Gordon-Lipkin, E. M., Ozturk, A., Caffo, B. S., Balcer, L. J., & Calabresi, P. A. (2009). Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Archives of Neurology, 66(8), 998-1006. https://doi.org/10.1001/archneurol.2009.107

Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. / Reich, Daniel S.; Smith, Seth A.; Gordon-Lipkin, Eliza M.; Ozturk, Arzu; Caffo, Brian S.; Balcer, Laura J.; Calabresi, Peter A.

In: Archives of Neurology, Vol. 66, No. 8, 08.2009, p. 998-1006.

Research output: Contribution to journalArticle

Reich, DS, Smith, SA, Gordon-Lipkin, EM, Ozturk, A, Caffo, BS, Balcer, LJ & Calabresi, PA 2009, 'Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability', Archives of Neurology, vol. 66, no. 8, pp. 998-1006. https://doi.org/10.1001/archneurol.2009.107
Reich, Daniel S. ; Smith, Seth A. ; Gordon-Lipkin, Eliza M. ; Ozturk, Arzu ; Caffo, Brian S. ; Balcer, Laura J. ; Calabresi, Peter A. / Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. In: Archives of Neurology. 2009 ; Vol. 66, No. 8. pp. 998-1006.
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