Daily rhythm of plasma melatonin in normal and precocious puberty

J. R L Ehrenkranz, L. Tamarkin, F. Comite, R. E. Johnsonbaugh, D. E. Bybee, Donald (Lynn) Loriaux, G. B. Cutler

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20-50 pg/ml) duing the day and high levels (80-100 pg/ml) at night between 0100-0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number2
StatePublished - 1982
Externally publishedYes

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Precocious Puberty
Melatonin
Plasmas
Puberty

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Ehrenkranz, J. R. L., Tamarkin, L., Comite, F., Johnsonbaugh, R. E., Bybee, D. E., Loriaux, D. L., & Cutler, G. B. (1982). Daily rhythm of plasma melatonin in normal and precocious puberty. Journal of Clinical Endocrinology and Metabolism, 55(2), 307-310.

Daily rhythm of plasma melatonin in normal and precocious puberty. / Ehrenkranz, J. R L; Tamarkin, L.; Comite, F.; Johnsonbaugh, R. E.; Bybee, D. E.; Loriaux, Donald (Lynn); Cutler, G. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 2, 1982, p. 307-310.

Research output: Contribution to journalArticle

Ehrenkranz, JRL, Tamarkin, L, Comite, F, Johnsonbaugh, RE, Bybee, DE, Loriaux, DL & Cutler, GB 1982, 'Daily rhythm of plasma melatonin in normal and precocious puberty', Journal of Clinical Endocrinology and Metabolism, vol. 55, no. 2, pp. 307-310.
Ehrenkranz JRL, Tamarkin L, Comite F, Johnsonbaugh RE, Bybee DE, Loriaux DL et al. Daily rhythm of plasma melatonin in normal and precocious puberty. Journal of Clinical Endocrinology and Metabolism. 1982;55(2):307-310.
Ehrenkranz, J. R L ; Tamarkin, L. ; Comite, F. ; Johnsonbaugh, R. E. ; Bybee, D. E. ; Loriaux, Donald (Lynn) ; Cutler, G. B. / Daily rhythm of plasma melatonin in normal and precocious puberty. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 55, No. 2. pp. 307-310.
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