TY - JOUR
T1 - Daily rhythm of plasma melatonin in normal and precocious puberty
AU - Ehrenkranz, Joel R.L.
AU - Tamarkin, Lawrence
AU - Comite, Florence
AU - Johnsonbaugh, Roger E.
AU - Bybee, David E.
AU - Loriaux, D. Lynn
AU - Cutler, Gordon B.
PY - 1982/8
Y1 - 1982/8
N2 - A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20–50 pg/ml) during the day and high levels (80–100 pg/ml) at night between 0100–0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.
AB - A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20–50 pg/ml) during the day and high levels (80–100 pg/ml) at night between 0100–0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.
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U2 - 10.1210/jcem-55-2-307
DO - 10.1210/jcem-55-2-307
M3 - Article
C2 - 7200991
AN - SCOPUS:0020360463
VL - 55
SP - 307
EP - 310
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -