Abstract
A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20-50 pg/ml) duing the day and high levels (80-100 pg/ml) at night between 0100-0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-310 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 55 |
| Issue number | 2 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Daily rhythm of plasma melatonin in normal and precocious puberty. / Ehrenkranz, J. R L; Tamarkin, L.; Comite, F.; Johnsonbaugh, R. E.; Bybee, D. E.; Loriaux, Donald (Lynn); Cutler, G. B.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 2, 1982, p. 307-310.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Daily rhythm of plasma melatonin in normal and precocious puberty
AU - Ehrenkranz, J. R L
AU - Tamarkin, L.
AU - Comite, F.
AU - Johnsonbaugh, R. E.
AU - Bybee, D. E.
AU - Loriaux, Donald (Lynn)
AU - Cutler, G. B.
PY - 1982
Y1 - 1982
N2 - A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20-50 pg/ml) duing the day and high levels (80-100 pg/ml) at night between 0100-0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.
AB - A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20-50 pg/ml) duing the day and high levels (80-100 pg/ml) at night between 0100-0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020360463&partnerID=8YFLogxK
M3 - Article
C2 - 7200991
AN - SCOPUS:0020360463
VL - 55
SP - 307
EP - 310
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -