Daily rhythm of plasma melatonin in normal and precocious puberty

Joel R.L. Ehrenkranz, Lawrence Tamarkin, Florence Comite, Roger E. Johnsonbaugh, David E. Bybee, D. Lynn Loriaux, Gordon B. Cutler

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Abstract

A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20–50 pg/ml) during the day and high levels (80–100 pg/ml) at night between 0100–0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number2
DOIs
StatePublished - Aug 1982

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ehrenkranz, J. R. L., Tamarkin, L., Comite, F., Johnsonbaugh, R. E., Bybee, D. E., Loriaux, D. L., & Cutler, G. B. (1982). Daily rhythm of plasma melatonin in normal and precocious puberty. Journal of Clinical Endocrinology and Metabolism, 55(2), 307-310. https://doi.org/10.1210/jcem-55-2-307