D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking

Christa Helms, N. R. Gubner, Clare Wilhelm, Suzanne Mitchell, David Grandy

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Alleles of the human dopamine D4 receptor (D4R) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psychopathologies are a result of attenuated D4R-mediated signaling, mice lacking D4Rs (D4KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D4KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D4R-mediated signaling may not affect impulsivity. D4KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D4Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume90
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Impulsive Behavior
Dopamine D4 Receptors
Genes
Psychopathology
Gambling
Attention Deficit Disorder with Hyperactivity
Substance-Related Disorders
Alleles
Genotype

Keywords

  • D receptors
  • Delay discounting
  • Go/No-go
  • Impulsivity
  • Inhibition
  • Locomotion
  • Mice
  • Novelty seeking

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. / Helms, Christa; Gubner, N. R.; Wilhelm, Clare; Mitchell, Suzanne; Grandy, David.

In: Pharmacology Biochemistry and Behavior, Vol. 90, No. 3, 09.2008, p. 387-393.

Research output: Contribution to journalArticle

Helms, Christa ; Gubner, N. R. ; Wilhelm, Clare ; Mitchell, Suzanne ; Grandy, David. / D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. In: Pharmacology Biochemistry and Behavior. 2008 ; Vol. 90, No. 3. pp. 387-393.
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